Xevo TQ-S

In this application note, Waters discusses using the ACQUITY UPLC I-Class system for highly sensitive MS methods, without compromising on important factors such as sample throughput.

In this application note, a comparison was performed between Oasis PRiME HLB SPE, SLE and LLE in both plasma and urine matrices for bioanalysis and forensic toxicology. In plasma, 22 comonly analyzed pharmaceuticals, steroids, and drugs of abuse were extracted using the three aforementioned methods and the results were compared. In urine, 23 drugs of abuse representing opioids, stimulants, benzodiazepines, and synthetic cannabinoid metabolites were tested for forensic toxicology analysis.

This application note presents a method to confirm and quantify the presence of macrolides and other important classes of antibiotics in wastewater treatment plant (WWTP) effluent and surface waters at low ppt levels.

The measurement of paracetamol, also known as Acetaminophen and it's derivatives, is a valuable means of studying the effects of the drug in both animals and humans. This application note describes a sensitive, validated, UPLC-based bioanalytical method for the quantification of acetaminophen and it's five metabolites.

In this application note, the differentiation of honeys from different botanical origin is demonstrated using an untargeted metabolomics approach via UPLC -MS/MS.

The trap-and-elute method is a powerful technique to extend the chromatographic capability of nanoLC/MS. It allows a large volume of sample to be injected with the risk of sacrificing peak shape or fouling the column. This study emphasizes the importance of selecting the appropriate stationary phases for the trap and column for proteomic trap-and-elute nanoLC/MS assays.

In Veterinary medicine, xylazine is an FDA approved tranquilizer often used in combination with ketamine. The recreational use of both drugs is on the rise in a number of countries. Recently, the cocktail has been reported as a date rape drug resulting in ketamine being re-classified as a Schedule III drug in the US. the analysis of xylazine and ketamine in biological samples presents a number of challenges to analysts. Hyphenated chromatography platforms have enabled the sensitivity and efficiency to detect trace levels of analytes previously unachievable by traditional means. The only bottleneck now is the lengthy sample preparation time required, which will inevitably delay forensic investigations.

This application note describes a sensitive LC-MS/MS quantification method for the robust analysis of highly polar pesticides in food commodities without the need of derivatization. Using the ACQUITY UPLC System coupled to the Xevo TQ-XS Triple Quadrupole Mass Spectrometer, they achieved sub-parts per billion detection (ppb) limits for glyphosate, glufosinate and aminomethylphosphonic acid (AMPA). The sensitivity of the Xevo TQ-XS promises excellent limits of detection, suitable for monitoring maximum residue limit (MRL) compliance for these challenging analytes and good quantitative performance, in terms of precision and calibration characteristics in compliance with SANTE 11954/2015 guidelines.

Join us at the 64th ASMS Conference on Mass Spectrometry and Allied Topics and find out more about Waters latest technologies and innovations that enable superior performance in your lab, allowing you to succeed in the science of what’s possible.

Starting on Saturday, June 4th, be sure to attend Waters MS Users’ Meeting at ASMS 2016 at the San Antonio Marriott Rivercenter, where you'll hear from renowned guest speakers, who are leading the way in the field of mass spectrometry and join other MS users at the afternoon parallel sessions covering key application areas.
Join us for breakfast June 6th, 7th and 8th at one of 7 informative technical seminars.

Get a sneak preview now of the many new mass spectrometry products and technologies we'll be showing you in our Waters Hospitality Suite in Texas Ballrooms B & C at the Grand Hyatt San Antonio.

Don't forget to review the various oral and poster presentations Waters experts will be giving and download the presentation schedule so you can add to your daily agenda.

See you at ASMS in San Antonio!

This application note describes a method to measure dioxins in a variety of sample matrices using Waters Atmospheric Pressure Gas Chromatography (APGC) with Xevo TQ-S. Dioxins are known to persist in the environment and pose significant toxicological concern, so testing is enforced globally.

In this video, Rudolf Krska from the University of Natural Resources and Life Sciences, discusses the types of contaminants that potentially occur in the food chain and explains how the latest integrated approaches using high resolution mass spectrometry can help mitigate these issues.

Liquid chromatography tandem mass spectrometry is advancing the analysis of clinical samples and helps improve efficiency in patient sample processing. Learn how Waters Xevo® TQ-S and ACQUITY UPLC® systems are being used at UC San Diego to develop new methods for accurate quantitation of analytes in a short amount of time.

Mass spectrometers from Waters Corporation are used for reliable detection of analytes in urine, blood and CSF, offering an attractive alternative to immunoassays. Watch this video to find out more.

Watch this video to hear Eric Soderblom, Staff Scientist at the Proteomics and Metabolomics Core Facility at Duke University, discuss his work on expression profile fingerprinting of tumor associate antigens across different cancer types. This important work would not be possible without the precise separating power of multi-dimensional LC-LC coupled with targeted MRM.

As a leading clinical LC-MS/MS solutions partner, Waters is a trusted provider of in vitro diagnostic medical devices, consumables, informatics, and support services for high performance LC-MS/MS systems. Learn how and why University Hospital of South Manchester has introduced Waters LC-MS/MS IVD instrumentation into their busy clinical laboratory.

Learn how Professor Frank Dorman’s team at Penn State University, PA, is using the increased sensitivity and method robustness offered by the Xevo TQ-S from Waters for selective and sensitive chemical analysis of water sources and chemotherapeutic drugs and the analysis of persistent environmental pollutants (POPs).

Watch this video to discover how the TOF mass spectrometers from Waters have led to advances in proteomics and metabolomics at Colorado State University. Their robustness and speed allows for non-targeting metabolite identification which has transformed agricultural breeding approaches.

Watch this video to find out about some of the clinical LC/MS devices available from Waters. Learn more about how this technology allows clinical laboratories to address an unmet need in areas from toxicology and therapeutic drug testing to endocrinology.

Watch this video to find out about the independent testing of dietary supplements by Analytical Laboratories to ensure that these meet FDA regulations. Analytical Laboratories analyzes complex, multi-ingredient samples and scans up to 300 pesticides in 1 run, using Waters ACQUITY UPLC systems coupled to Xevo MS. This enables fast analysis with high resolution whilst providing savings on reagents compared to traditional HPLC.

In this video the features of the Xevo TQ-S are explained. The Xevo TQ-S is part of the advanced bench top mass spectrometer family from Waters Corporation and partners the ACQUITY UPLC system. This system enables quantification of compounds at lower concentrations than previously thought possible. The information rich acquisition mode (RADAR) alternates between MRM and full scan MS acquisition modes.

Waters enables core product portfolio with next-generation automation technology

We look back at a selection of this year’s best interviews with some of the world's leading experts

Simplify the task of removing pesticide and herbicide residues to meet regulatory standards with these vital resources

SelectScience will be attending this year's American Society of Mass Spectrometry annual conference to bring you the latest news and technology in mass spectrometry

A mass spec scientist, from a world-renowned clinical pathology laboratory, shares the secrets to their success in this exclusive SelectScience interview

Find out how this busy UK biochemistry department has implemented mass spectrometry for clinical practice, for improved specificity and cost-efficiency

Prepare for the American Society for Mass Spectrometry(ASMS) Annual Meeting by discovering the many applications of mass spectrometry – from pesticide detection to imaging for cancer therapy

Don't miss this exclusive buying advice