Strata-X Polymeric SPE

In this poster, Phenomenex presents an effective sample cleanup method for oral fluid analysis. The method utilizes a mixed mode strong cation exchange Strata™-X-C microelution 96-well plate for sample cleanup and a Kinetex™ core-shell 2.6 µm Biphenyl column for fast chromatographic separation. The poster includes a representative chromatogram, linearity curves, and mutiple-reaction monitoring (MRM) transitions and linearity data for 32 pain panel analytes in oral fluid. It addresses the challenges of analyzing oral fluid samples and provides a solution using specific equipment and techniques.

Explore HPLC column choices and sample preparation options for diverse sample matrices, separation selectivities, and workflows. Download this application note to find the latest word on PFAS analysis - but certainly not the final - on this rapidly expanding field of investigation.

This application note details some common problems caused during environmental sample analysis and provides solutions through a wide variety of sample preparation kits.

The world is changing and we need to widen our Environmental Scope. Although analytical techniques and established regulated methods are not easily changed; more complex targets, larger lists, and a variety of sample matrices create a daily challenge for environmental chemists. By using the latest technologies and techniques in HPLC/ UHPLC and Sample Preparation, laboratories and chemists are able to develop better approaches to make their work Faster, Cheaper and Easier. Phenomenex is committed to supporting the industry through a comprehensive product portfolio of Sample Preparation, HPLC/UHPLC, and LC-MS, columns and accessories, along with application and method development services to meet industry needs.

This application note discusses sample preparation techniques for a variety of clinical samples for simplified liquid extractions (SLE) and solid phase extraction (SPE).

This clinical notebook contains a variety of 36 application notes, covering topics in endocrinology and biomarker research, therapeutic drug monitoring, toxicology and sample preparation.

This application note gives a complete and comprehensive guide to developing your SPE method, including choosing a sorbent, pre-treatment of the sample, general starting methods for Strata-X and for Strata, industry applications and ordering information.

Diclofenac is a post-operative pain reliever that has also been shown to diminish the formation of the pro-inflammatory hormones. This application note describes the use of two popular extraction methods, solid phase extraction (SPE) and liquid-liquid extraction (LLE), for the isolation of diclofenac from plasma using Strata-X SPE. This article demonstrates the capability of Strata-X SPE to retain hydrophobic neutral compounds as well as acidic and basic compounds.

Ensuring that sample extracts are clean can extend the life of costly analytical instruments, however sample preparation method development can be a laborious and time intensive process. This application note suggests how a simplified method of solid phase extraction (SPE) can be devised using a Strata-X 96-Well SPE Method Development (MD) Plate (Phenomenex) in conjunction with Tecan Freedom EVO liquid handling system.

Solid phase extraction is an effective technique for cleaning up and concentrating samples. This application note outlines an approach for solid phase extraction method development using Strata® and Strata TM-X SPE sorbents that is simple, reproducible and highly efficient.

In this webinar, Dr. Stephanie Marin, Global Clinical Market Development Manager at Phenomenex, will provide a comprehensive overview of polymeric mixed-mode solid phase extraction (SPE) fundamentals and the properties of polymeric hydrophobic interaction (reversed-phase) SPE sorbents. Attendees will learn how to choose the appropriate SPE phase for their specific compounds of interest, along with an explanation of the ionic functional groups that provide the mixed-mode functionalities, including both weak and strong cation and anion exchange.

Dr. Marin will also delve into the initial extraction conditions required to initiate method development for each type of SPE sorbent, as well as specialized SPE products tailored for drug testing, phospholipid removal, and microelution SPE. This webinar will include numerous clinical research applications to exemplify these concepts.

Key learning objectives

• Discover how to differentiate different polymeric mixed-mode SPE sorbents
• Explore starting conditions for each sorbent type
• Learn how to choose the best SPE sorbent for different analytes
• Understand how to use an SPE method development plate

Who should attend?

• Scientists doing SPE method development
• Labratorians who want to increase their knowledge of polymeric mixed-mode SPE
• Lab managers who want to implement SPE methods in their laboratories

Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.

Alkemist Labs, an industry leader in botanical testing, highlights the importance of reliable equipment and harmonized practices in the rapidly changing cannabis landscape

Phenomenex’s sample preparation product manager shares his expert advice on preparing challenging biological sample matrices for LC-MS/MS

Richard Thomas, CSO, Precision Diagnostics, discusses use of HPLC at leading drug detection laboratory