PAL RTC

Per- and polyfluoroalkyl substances (PFAS) are persistent chemicals with water and oil repellent properties, used in a large variety of products but posing environmental and health risks. A survey conducted by 'the Analytical Scientist' revealed that 'Sample Preparation' ranks top among the main challenges for PFAS analysis, while 'Eliminating background interference' emerges as the most desirable factor for improving sensitivity.

Explore solutions to these common challenges including the PAL Systems which provide automated sample preparation to reduce errors and improve repeatability, as well as offering PFAS-free products to minimize background contamination for optimal sensitivity and accuracy.

Explore an automated parallel derivatization strategy with Dansyl-Cl and Dansyl-N2H3 for broad metabolite coverage in LC-MS workflows. By enhancing retention time, signal-to-noise ratio, and reaction control through on-line SPE fractionation, the method improves qualitative and quantitative metabolomics. Using labeled (13C) derivatization agents with SWATH/MS data acquisition enables precise metabolite analysis, addressing limitations in polar metabolite detection and quantification.

Dive into the realm of sample preparation, a crucial part of the pre-analytical phase, exploring how automation – particularly using x,y,z robots and innovative tools for streamlining extraction procedures – transforms workflows for laboratories relying on liquid chromatography/mass spectrometry (LC/MS) and gas chromatography/mass spectrometry (GC/MS). Beyond this, these workflows may also serve as an inspiration for other analytical platforms.

Rice is the seed of Oryza sativa L. and aromatic rice varieties have recently gained wider acceptance across the globe. Because of their characteristic aroma and flavor, they are highly favored and command higher prices in rice markets. Thus the ability to analyze flavor profiles is relevant to food quality laboratories. The rice seed itself usually does not release flavor or aroma compounds. By cooking in continuous boiling water for about 10 minutes, the fragrance components are released. The fragrance products might be formed through the Maillard reaction. In this application note, CTC Analytics introduces a simple, reliable, and full automated method for boiling and analyzing rice samples.

In this application note, the volatile compounds of Durian were extracted with two different headspace modes, static and dynamic headspace modes under relatively mild heat. Static headspace is mostly used to analyze the most abundant volatile compounds. While, dynamic headspace, due to its ability to concentrate analytes, can detect compounds even in the parts per billion (ppb) range down to the odor thresholds. Both headspace methods work fully automated and solventless, which is a big advantage in reducing manual labor-intensive work and provides a green analytical method to laboratories.

This application note describes the optimization of residual solvents analysis according to USP and Ph. Eur. 2.4.24 using the automated syringe headspace technique on GC-FID and GCMS systems. The precision of analysis ranged from 4.3 to 7.8 % RSD (GC-FID) for class 2 solvents for all analytes investigated in this study. These values fully comply with USP and Ph. Eur. 2.4.24 requirements.

This protocol demonstrates how FAME preparation, including injection into the GC, can be fully automated using the PAL RTC workstation to improve process safety, throughput, and traceability.

In this application note, CTC Analytics presents a fully automated sample preparation method that has been developed and tested for extraction and analysis of drugs of abuse from hair samples.

In this application note, CTC Analytics discusses the necessary parameters to automatically prepare whole blood samples for online LC-MS applications in the field of diagnostics and TDM.

In this application note, CTC Analytics covers the development and use of miniaturized cSPE for QuEChERS, using Instrument Top Sample Prep cartridges automated on a PAL System autosampler.

In this video, CTC Analytics demonstrates the uSPE workflow.

Discover how prioritizing reproducibility and method validation can empower researchers to unlock the full potential of metabolomics in advancing biomarker discovery and drug development

Exploring food safety monitoring, USDA expert, Steve Lehotay, advocates for change, and highlights the need for innovation in current practices to enhance routine analysis

Samer Sansil shares his inspiration to pursue cancer research and highlights why working together and learning from others is key to advancement