Headspace analysis: reproducibility of syringe headspace injections for aqueous samples

This application note describes the optimization of residual solvents analysis according to USP and Ph. Eur. 2.4.24 using the automated syringe headspace technique on GC-FID and GCMS systems. The precision of analysis ranged from 4.3 to 7.8 % RSD (GC-FID) for class 2 solvents for all analytes investigated in this study. These values fully comply with USP and Ph. Eur. 2.4.24 requirements.