MALDI-8020 Benchtop MALDI-TOF Mass Spectrometer
Providing a dependable, robust, and easy-to-maintain platform, Shimadzu’s benchtop MALDI-8020 delivers sensitive detection and accurate mass determination by MALDI-TOF MS for a variety of analytes.
Benchtop MALDI-8020 Mass Spectrometer
Dr. Tom Spudich, Professor of Analytical Chemistry, discusses the advanced spectroscopy tools that are transforming forensic science
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Through innovative instrument design, the space-saving MALDI-8020 achieves performance specifications similar to those of larger, more expensive MALDI-TOF models but in a significantly smaller footprint. The MALDI-8020 improves laboratory efficiency and accelerates analysis through a newly designed load-lock system for rapid sample target introduction and a solid-state laser for fast data acquisition speeds. Using linear time of flight, this compact MALDI-TOF system enables low-level detection of proteins, peptides and polymers, among other analytes. In addition, it easily accommodates standard laboratory workflows such as peptide mass finger printing for simple protein ID confirmation, in-source decay (ISD) and polymer distribution analysis.
Key features include:
• Compact benchtop design
• Rapid loading and acquisition
• Automated source cleaning
• Integrated barcode scanner
The MALDI-8020, operated by MALDI Solutions software, is ideally suited for pharmaceutical QC labs as well as academic and industrial labs with limited laboratory space. MALDI Solutions offers intuitive, yet secure, operation, including security, audit trails and user management, to help meet 21 CFR Part 11 compliance. Additionally, the simple and intuitive user interface makes this an ideal teaching tool.
Determination of the presence of the number of modifications using a linear benchtop MALDI-TOF MS
Explore the analysis of antibody-drug conjugates (ADCs), combining antibody selectivity with small-molecule drugs for targeted cancer therapy. Using its MALDI 8020 Benchtop Linear MALDI-TOF Mass Spectrometer, Shimadzu demonstrates how to determine binding sites and characteristics of pseudo ADCs, created by binding low-molecular compounds to research antibodies. This method supports quality assessment and development of ADCs in pharmaceutical research.
Sequence analysis of antisense nucleic acid using a MALDI-8030 benchtop MALDI-TOF mass spectrometer
MALDI-ISD fragmentation of nucleic acids provides successive fragment ions by simple cleavages and is a highly useful tool for simple sequencing of nucleic acids. This application note from Shimadzu describes an example of sequencing antisense nucleic acids by ISD fragmentation using a Shimadzu MALDI-8030 benchtop linear MALDI-TOF mass spectrometer.
Protein and peptide mass spectrometry imaging on the MALDI-8020 benchtop MALDI-TOF mass spectrometer
In this application note, Shimadzu demonstrates the capability of its imaging platform to easily achieve quality mass spectra and MS images for intact proteins from tissue sections and for peptides following on-tissue digestion, with linear mode analysis of rat brain tissue.
Analysis solutions to fight food fraud
This application note from Shimadzu introduces an example of simple and rapid identification of vegetable oils, using a benchtop MALDI-TOF MS and the eMSTAT Solution statistical analysis software.
Speeding up forensics with advanced spectroscopy tools
Dr. Tom Spudich, Professor of Analytical Chemistry, discusses the advanced techniques like UV-Vis spectroscopy, GC-MS, FTIR with ATR, and ICP-OES that are transforming forensic science workflows. Hear how these methods have been instrumental in projects that range from preserving historic documents through metal content analysis to detecting beverage adulterants like 1,4-butanediol, a GHB precursor. Spudich shares how faster, more sensitive analytical tools, are enabling his team to analysis time from hours to just 15 minutes, boosting efficiency and sample throughput. With smarter instrumentation, forensic analysis is becoming faster, more selective, and more accessible than ever before.
