ResourceSpectroscopy
Sequence analysis of antisense nucleic acid using a MALDI-8030 benchtop MALDI-TOF mass spectrometer
1 Jun 2023MALDI-ISD fragmentation of nucleic acids provides successive fragment ions by simple cleavages and is a highly useful tool for simple sequencing of nucleic acids. This application note from Shimadzu describes an example of sequencing antisense nucleic acids by ISD fragmentation using a Shimadzu MALDI-8030 benchtop linear MALDI-TOF mass spectrometer.
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MALDI-8020 Benchtop MALDI-TOF Mass Spectrometer
Shimadzu CorporationProviding a dependable, robust, and easy-to-maintain platform, Shimadzu’s benchtop MALDI-8020 delivers sensitive detection and accurate mass determination by MALDI-TOF MS for a variety of analytes.
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MALDI-TOF MSMALDI-TOF mass spectrometers (matrix-assisted laser desorption/ionization time-of-flight) are used for the mass analysis of large molecules, including proteins, DNA, polymers and other macromolecules due to its relatively soft ionization, reducing fragmentation whilst allowing fast data acquisition. Tandem mass analyzers such as TOF/TOF systems can be used to increase resolution and sensitivity of your analysis. Find the best MALDI-TOF products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer.
Nucleic Acid Concentration