ResourceSpectroscopy
Determination of the presence of the number of modifications using a linear benchtop MALDI-TOF MS
20 Jan 2025Explore the analysis of antibody-drug conjugates (ADCs), combining antibody selectivity with small-molecule drugs for targeted cancer therapy. Using its MALDI 8020 Benchtop Linear MALDI-TOF Mass Spectrometer, Shimadzu demonstrates how to determine binding sites and characteristics of pseudo ADCs, created by binding low-molecular compounds to research antibodies. This method supports quality assessment and development of ADCs in pharmaceutical research.
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MALDI-8020 Benchtop MALDI-TOF Mass Spectrometer
Shimadzu CorporationProviding a dependable, robust, and easy-to-maintain platform, Shimadzu’s benchtop MALDI-8020 delivers sensitive detection and accurate mass determination by MALDI-TOF MS for a variety of analytes.
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MALDI-TOF MSMALDI-TOF mass spectrometers (matrix-assisted laser desorption/ionization time-of-flight) are used for the mass analysis of large molecules, including proteins, DNA, polymers and other macromolecules due to its relatively soft ionization, reducing fragmentation whilst allowing fast data acquisition. Tandem mass analyzers such as TOF/TOF systems can be used to increase resolution and sensitivity of your analysis. Find the best MALDI-TOF products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Protein QuantificationThe detection and quantification of proteins in a sample is vital across life sciences, pharmaceutical research and clinical diagnostics, and a variety of equipment is available to scientists to simplify the workflow. Proteins of interest can be easily labeled and detected on light-based detection instruments. Immunoassay kits allow you to identify a specific protein of interest and protein detection beads or antibody microarrays allow you to identify multiple specific proteins at once. Protein interactions and enzyme activity can also be monitored with protein-protein interaction assays. Additionally, the biophysical characterization of proteins is made easy with biokinetic analyzers. Find the best protein detection and quantification products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.