Q-TOF LCMS-9030
Offering effortless Q-TOF LCMS performance, the LCMS-9030 allows users to perform critical qualitative and quantitative analysis with genuine confidence and ease.
Q-TOF LCMS-9030
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The LCMS QTOF 9030 stands out for its exceptional high-resolution mass spectrometry, delivering accurate and sensitive results. Its intuitive interface and efficient workflow boost productivity, and its advanced data acquisition capabilities offer in-depth molecular analysis. It remains a valuable tool for complex research tasks.
Biopharma
As a user of the LCMS QTOF 9030, I’ve been thoroughly impressed with its performance and versatility. The high-resolution mass spectrometry capabilities offer exceptional accuracy and sensitivity, making it a valuable tool for complex quantitative and qualitative analyses. The system’s user-friendly interface and streamlined workflow significantly reduce setup time and enhance productivity. I particularly appreciate the instrument’s robust data acquisition and analysis features, which provide detailed insights into molecular structures and dynamics. Overall, the LCMS QTOF 9030 has proven to be a powerful asset in our lab, delivering reliable results and supporting a wide range of research applications.
Review Date: 11 Sept 2024 | Shimadzu Corporation
The LCMS-9030 quadrupole time-of-fight (Q-TOF) mass spectrometer integrates the world’s fastest and most sensitive quadrupole technology with powerful TOF architecture to transform high mass accuracy workflows by achieving high-sensitivity, high-speed, and high-resolution detection.
The LCMS-9030 Q-TOF delivers outstanding mass accuracy over a wide mass range, enabling users to consistently produce accurate identification results. The need for infrequent calibration makes it easy to achieve high mass accuracy over long periods. High efficiency ion guides, quadrupole, and collision cell enable high sensitivity for the detection of trace level compounds. And, due to its robust platform, the LCMS-9030 achieves reproducible quantitative analysis over longer periods of time.
The LCMS-9030 incorporates the patented ultrafast technologies used in Shimadzu LC-MS/MS platforms to deliver outstanding speed. Innovative TOF architecture, such as the iRefTOF reflectron technology, which generates an ideal reflectron field, enables precise, ultra-fast pulsing of ions into the flight tube and ideal reflection back to the detector. The result is high-speed data acquisition compatible with the high-throughput laboratory.
A fast and simple workflow for mAb post-translational modifications study using LCMS-9030 Q-TOF
During drug development, it is crucial to closely monitor the changes in the post-translational modification (PTM) amino acid relative site abundance percentage values, such as methionine (M) oxidation or asparagine (N) deamidation, as it can impact the efficacy, stability and immunogenicity of monoclonal antibodies (mAbs).
Explore a simple and straightforward workflow to quantify the amino acid site relative abundance using peptide mapping analysis. Discover how a Shimadzu LCMS-9030 QTOF mass spectrometer coupled with Protein Metrics software provides high mass resolution to accurately identify, separate, and quantify the modified peptides with small mass shift differences. The use of peptide mapping analysis for PTM study can provide valuable insights into the mAbs characteristics to support early to late-stage drug development.
Multi-charged ion analysis of intact antibodies using a Q-TOF mass spectrometer
Explore the use of mass spectrometry for characterizing antibody drugs, including monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs). Shimadzu examines the challenges of structural heterogeneity in antibody production and introduces examples of analyzing pseudo ADCs with MALDI-TOF MS and trastuzumab with its LCMS-9030 quadrupole time-of-flight (Q-TOF) mass spectrometer. The LCMS-9030 integrates quadrupole technology with TOF capabilities for accurate mass measurement. Techniques like charge deconvolution aid in molecular weight and glycosylation analysis, ensuring drug quality and efficacy.
Revealing the invisible web: Solutions for an efficient analysis of PFAS
In this application note, Shimadzu discusses the challenges and solutions for per- and polyfluorinated alkyl substances (PFAS) analysis, including how to avoid sample contamination and sample loss, and how to optimize data processing. PFAS are a family of synthetic chemicals resistant to degradation and accumulate in the environment and living organisms, posing risks to humans and ecosystems. Shimadzu’s LC-MS/MS instruments and LabSolutions Insight software can streamline PFAS analysis, automate QA/QC flagging, and ensure data integrity. The use of PFAS-free containers, avoiding storing samples in glass, and SPE cartridges tests are necessary to avoid sample contamination.
Solutions for infectious diseases
In this application note, Shimadzu Corporation introduces three analytical instruments to evaluate infectious diseases caused by harmful microorganisms: liquid chromatography-mass spectrometer (LC-MS), matrix assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOF MS), and gas chromatography-mass spectrometer (GC-MS). The note highlights the rise of bacterial infectious diseases in the past 10 years, emphasizing the importance of investigating and examining these infections.
