CLARIOstar® Plus Multi-mode Microplate Reader
Most flexible Multi-mode Microplate Reader for Assay Development
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BMG plate readers are a great addition to any lab
Cancer Research
We have been using BMG Labtech plate readers for around 15 years now in my laboratory. We initially started with a PHERAstar Plus, but have since moved to buying two of the more flexible CLARIOStar Plus instruments to support a wide range of microtitre plate applications with greater ease (the LVF monochromator design is great!). We have been so pleased with the performance of BMG plate readers over time - they are extremely reliable and the customer support received by the BMG team is absolutely fantastic. My lab serves around 350 different scientists a year (my lab is a centralised core facility for an entire research Institute) and so reliability, flexibility and user-friendliness of the BMG equipment and software as well as excellent customer support is absolutely key. I can say that BMG excels at all.
Review Date: 9 Dec 2025 | BMG LABTECH
ClarioStar is the best plate reader you can have.
Cell based assays
I've used my Clariostar for years, its reliable, low maintainance, an I can establish new assays with such an ease, as I can scan each fluorophore. Its also so easy as I dont have to buy new filters every time I need another flurophore. What I really love about it, is that you can also upgrade with new technologies as Luminescence or Injection, so no need to buy new - which means less waste! Furthermore the support by the field an inhouse application specialists has always been timely and helpful.
Review Date: 22 Jul 2025 | BMG LABTECH
Great instrument with a wide range of capabilities, even better service.
Enzyme assays, cell based assays (Calcium flux, viability, caspase mediated apoptosis, drug/receptor assays via HTRF)
The Clariostar is simple to setup, the UI is easy to navigate and customise. It performs well, with excellent reproducibility and very fast read times. Setting up injector protocols can be tricky but the support from BMG Labtech easily overcomes any issues and their expertise and advice in these types of situations is invaluable, so too when troubleshooting is required.
Review Date: 14 Jul 2025 | BMG LABTECH
Good service, good instrument
Pharmaceuticals
Very fast delivery, good servive.
Review Date: 26 Jul 2024 | BMG LABTECH
Great plate reader!
ELISA
Great plate reader that we use for all our 96 well plate assays requiring an absorbance or fluorescent read out. Great for everything from growth curves to reading ELISAs. It has a decent absorbance/ fluorescence spectrum and the analysis software is useful and easy to use.
Review Date: 25 Jul 2024 | BMG LABTECH
Broad spectrum functionalities plate reader for advanced kinetics etc.
Microplate reading w/ kinetics and temperature gradients
Great product, very advanced settings and possibilities. Far more functions than usual plate reader. Sometimes a bit complicated because of the amount of functions.
Review Date: 25 Jul 2024 | BMG LABTECH
ClarioStar Plate Readers provide top-notch measurements with high throughput and precision
Research in Plant Physiology and Signaling
Our lab is equipped with 5 ClarioStar Plus Plate Readers, which are equipped with standard fluorescence intensity and absorbance measurement modules and additional different specific features for injections, fluorescence lifetime measurements, atmospheric control or luminescence measurements. Upon request BMG Labtech provided specific software additions for custom use purposes and are always very friendly when responding to individual questions concerning usage. The readers are highly usable in different research areas within our research group. The device and software are easy to use, and thus can not only be used in research, but also for student teaching courses on fluorescent biosening. The readers provides high quality data with top-notch precision at a high throughput level. In our opinion the BMG LABtech readers are the best available device of this kind on the market.
Review Date: 24 Jul 2024 | BMG LABTECH
Very good product, reliable and easy to use.
Materials Science
I have used the CLARIOstar Plus platereader since 2021 and the overall experience has always been good. I used it to run fluorescence and absorbance assays and it always proved to be reliable and easy to use. When one part of the machine broke, it was repaired in less than one week by the BMG technicians.
Review Date: 24 Jul 2024 | BMG LABTECH
Very good and useful instrument
Fluorescence polarization
The instrument design and operation are user friendly. Software usage is self explanatory, but it needs training to master it. Sensitivity and results reproducibility are the best characteristics. It is also easy to do maintenance.
Review Date: 24 Jul 2024 | BMG LABTECH
Excellent product
Microbiology
Very user friendly device with multimodal assay options that are easy to programme. Excellent customer service for all devices. Really quick and helpful answers are provided by the BMG team.
Review Date: 24 Jul 2024 | BMG LABTECH
The CLARIOstar® Plus is the most-sensitive monochromator-based microplate reader.. This high-performance multi-mode microplate reader from BMG LABTECH is equipped with revolutionary LVF MonochromatorsTM, spectrometer, and filters. Patented LVF Monochromators™ include cutting-edge technology, such as linear variable filters and a linear variable dichroic mirror. These provide the highest flexibility while delivering filter-like performance for fluorescence and luminescence assays including FRET and BRET. There is no compromise when it comes to sensitivity and flexibility, making the CLARIOstar Plus the leading microplate reader in its class. The Enhanced Dynamic Range and autofocus technologies significantly improve usability, making manual settings superfluous and detection optimisation easier than ever.
Features of the CLARIOstar Plus multi-mode microplate reader include:
- LVF Monochromators™ with continuously adjustable bandwidths from 8 to 100 nm allow more light for excitation and emission, resulting in greater sensitivity
- Largest dynamic range with no manual intervention - Rapid full-plate autofocus
- Increased flexibility with dedicated detectors
- Top and bottom reading for fluorescence and luminescence assays using monochromators or filters
- Combine filters and monochromators in the same measurement for higher flexibility in any fluorescence or luminescence assay
- High-speed, full spectrum UV/vis absorbance (220 to 1000 nm in < 1 second per well)
- Advanced detection modes: fluorescence polarization, time-resolved fluorescence, TR-FRET and AlphaScreen®
- Dedicated, high-energy laser for AlphaScreen® and AlphaLISA® assays
- Dedicated features for live cell-based assays including Atmospheric Control Unit
- Ultra-fast data sampling (100 measurements/second) for fast kinetics
The Atmospheric Control Unit (ACU) allows independent, simultaneous control of both O2 and CO2 within the microplate reader chamber. Ranging from standard cell growth assays to cytotoxicity assays, the ACU provides the optimal environment for any live cell-based assay. As a unique function, the CLARIOstar Plus with ACU can run gas ramps and mimic pathological conditions such as ischemia/reperfusion and hypoxia in vitro.
Accessories
- Atmospheric Control Unit (ACU): provides the ideal environment for cell-based assays by regulating O2 and CO2 gas levels in the microplate reader
- Filters and Optic Modules: standard filters from 240 - 850 nm, filters and Optic Modules optimised for specific applications, and bespoke solutions are available
- Microplate Stacker: optimises microplate handling and increases throughput by providing rapid loading, unloading, restacking, and continuous feeding for up to 50 microplates
- LVis Plate: microplate for low-volume DNA, RNA and protein quantification. It includes 16 micro-drop (2 µL) wells, a cuvette slot and optional performance testing features
- Evaluation Plate: validates the optical functionality of BMG LABTECH microplate readers for quality control and/or qualification (IQ/OQ) purposes
Brochures
CLARIOstar Brochure
This product brochure outlines the features of the CLARIOstar microplate reader, including enhanced sensitivity and flexibility achieved through its three separate detection technologies: LVF Monochromators, Spectrophotometer and Filters. The article highlights the benefits of CLARIOstar over other microplate readers, its many different applications and technical specifications.
Lipid peroxidation assay in an ischemia-reperfusion cell model with NCLX inhibitors using the CLARIOstar Plus
Ferroptosis is an iron-dependent form of cell death driven by oxidative damage to membrane lipids, implicated in neurodegenerative diseases. Reactive oxygen species (ROS) generated during hypoxia-reoxygenation, via the mitochondrial NCLX sodium/calcium exchanger, promote lipid peroxidation and cell death. Here, the CLARIOstar Plus microplate reader was used to measure the inhibition of lipid peroxidation in a fluorescence–based lipid peroxidation assay while changing oxygen levels with the Atmospheric Control Unit (ACU).
THUNDER assays for ERK1/2, p38αβγ and STAT3
Discover how THUNDER™ TR-FRET assays on the CLARIOstar Plus enable fast, sensitive, and cost-effective detection of phosphorylated proteins like ERK1/2, p38αβγ, and STAT3 in whole-cell lysates for high-throughput cellular kinase research.
Microplate-based assays in virology research
In this eBook, BMG LABTECH delves into the current microplate-based assays utilized in virology research, uncovering the novel insights these assays offer and their impact on the field. The recent COVID-19 pandemic highlighted the profound impact viruses can have on health, society, and the economy, reigniting interest in virology. Modern virology aims to understand and characterize viruses for diagnostic tests, antiviral drugs, and vaccines. Microplate-based assays and plate readers have become indispensable tools in this pursuit, providing researchers with flexible and efficient means to gather objective and reproducible data for monitoring viral infections in real-time.
Microplate-based assays in microbiology research
In this eBook, BMG LABTECH discusses microplate-based assays in microbiology research, covering the use of microplate readers in microbiology research applications. It highlights the advantages of using microplate-based assays for monitoring microbial growth and viability, functional assays, and high-throughput screening for antimicrobial compounds. The eBook explores different types of microplate-based assays that can be used in microbiology research and provides application notes on various assays, including growth, detection, and monitoring of bacteria, yeasts, and viruses. The eBook serves as a comprehensive guide for microbiologists looking to leverage the benefits of microplate-based assays in their research, and is recommended for those who want to perform time and cost-efficient microbiology assays.
Measuring protein ligand binding with an endogenous HiBiT CETSA test system
In this application note, BMG LABTECH introduces the HiBiT CETSA, a method for measuring protein-ligand binding in a tracer-free manner. This approach can improve the screening for new ligands by allowing the measurement of endogenous full-length proteins. The HiBiT CETSA detects interactions between proteins and potential ligands by determining the protein's melting point along a heat gradient. The assay allows plotting the temperature against the detected luminescence, and subsequently, the melting curves are analyzed to identify compound-induced thermal shifts.
The Advanced Assay Stability system for temperature-sensitive assays
In this application note, BMG LABTECH discusses the limitations of conventional microplate readers when it comes to temperature stability and its effects on assay precision and reliability. The PHERAstar® FSX with Advanced Assay Stability (AAS) system eliminates external air flow to the inside of the reader, maintaining constant humidity and reducing evaporation. The AAS system enables the PHERAstar FSX to match room temperature conditions and to be maintained at any temperature between 18° and 45°C. It achieves this by automatically heating or cooling the microplate measurement chamber depending on the external environment.
Real-time cell motility tracking increases the throughput of scratch wound assays
In this application note, BMG LABTECH discusses the use of microplate readers for measuring the motility of cells, specifically in the context of wound healing and invasion assays. The note describes important factors to consider when performing these assays, such as the choice of a proper cell line, the selection of the right assay format, and the attainment of proper cell confluency prior to the assay. The note also discusses the use of key detection technologies such as fluorescence, luminescence, and absorbance, comparing the benefits and drawbacks of each technology.
Get the best out of your microplate reader
Discover tips and considerations for improving microplate reader measurements. Application specialists, Dr. Ann-Cathrin Volz and Dr. Martin Mangold from BMG LABTECH, discuss the impact of different plate reader parameters on data, and provide empirical evidence of their effect on data quality. They also discuss approaches to optimize microplate reader settings, and share recommendations for using BMG LABTECH's range of microplate readers.
Luxury or necessity: Which features should I have on my plate reader?
In this video, Eric Matthews, Vice President of Sales at BMG LABTECH USA, discusses the features to look out for when looking to purchase a new microplate reader. Plus, Matthews explores what technologies contribute to reader performance and when trade-offs between performance and flexibility may be worthwhile.
The role of cell-based assays in the modern lab, beyond the petri dish
This special feature explores the latest research, applications, and advances in cell-based assay technology
Our biggest ever Seal of Quality announcement
Here we recognize the latest products to earn a coveted Seal of Quality award for receiving consistently outstanding feedback from scientists
