Onco-Hu mouse models for cancer research
7 Apr 2024
Mouse models serve as essential tools for studying tumor development, progression, and response to therapies. Genetically engineered mice can mimic human cancer mutations, allowing researchers to investigate the molecular mechanisms underlying cancer initiation and progression. Dr. Brian Soper from The Jackson Laboratory explores Onco-Hu® models, a robust immuno-oncology platform for efficacy testing of novel immunotherapies targeting T cells and myeloid cells. The platform is based on NSG™ and NSG™-SGM3 transgenic mice, dually engrafted with human CD34+ hematopoietic stem cells (HSCs) and clinically relevant PDX Live™ low passage tumors.
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The Jackson Laboratory
The Jackson Laboratory is a global leader in preclinical studies and has been driving therapeutic development breakthroughs for over 90 years. With the most innovative preclinical platforms including humanized mice, and services such as dose ranging, toxicity, and efficacy studies, JAX empowers drug developers and researchers worldwide.
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The Jackson LaboratoryTake advantage of our large inventories of common inbred strains and the convenience of having your breeding and drug efficacy needs met by the leading experts in mouse modeling.
