Immune humanized mouse platforms for pre-clinical applications
8 Apr 2024
The highly immunodeficient NSG™ platform enables precise in vivo modeling of human immune responses, providing researchers with a powerful tool for characterizing and validating immune-modulating therapeutics. Dr. Charu Gupta, technical information scientist from the Jackson Laboratory, compares strategies for immune humanization of NSG variants to support translatable preclinical immunology and oncology research. Learn about techniques for humanizing immune cells using the NSG platform, the effects of host selection and genetic modifications on immune phenotypes, and novel NSG variants enhancing human innate immune cell development.
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The Jackson Laboratory
The Jackson Laboratory is a global leader in preclinical studies and has been driving therapeutic development breakthroughs for over 90 years. With the most innovative preclinical platforms including humanized mice, and services such as dose ranging, toxicity, and efficacy studies, JAX empowers drug developers and researchers worldwide.
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