Screening developability and pre-formulation of biotherapeutics with high-throughput dynamic light scattering
21 Jul 2022As the pharmaceutical industry targets increasingly complex biologic candidates, automated formulation and analytical workflows play an important role in streamlining the development process. Explore the technology that powers automated high-throughput dynamic light scattering (HT–DLS) and its practical applications in candidate and formulation selection. Capable of performing 96 runs in under 45 minutes and 384 wells in 1.5–2 hours, with completely unattended operation, discover how high-performance HT–DLS accelerates analysis time, reduces the need for expert operator supervision, and improves confidence in data quality.
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DynaPro™ NanoStar™ II Dynamic Light Scattering Detector
Waters | Wyatt TechnologyThe DynaPro™ NanoStar™ II DLS instrument determines size and molar mass with as little as 2 µL of solution.
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High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Dynamic Light ScatteringDynamic light scattering is used to measure the size distribution of particles in suspension by analyzing the way light scatters off them. It is commonly used in materials science, nanotechnology, and protein characterization. Browse our peer-reviewed product directory to find the best dynamic light scattering systems, compare products, check reviews, and get pricing directly from manufacturers.FormulationFormulation is the process of combining active pharmaceutical ingredients with excipients to produce a drug which is both stable and active.BiotherapeuticsBiotherapeutics are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or in <i>in vivo</i> diagnostics. The most well-known example of a biotherapeutic product, and the first to be approved for therapeutic use, was recombinant human insulin.ScreeningUsing robotics, data processing and control software, liquid handling devices and sensitive detectors, screening allows a researcher to quickly conduct millions of chemical, genetic or pharmacological tests.