Protein Crystallography Products & Reviews

Automated membrane protein screening, optimization, and scale-up to empower better protein crystallization research. 

mosquito crystal helps scientists to automate and streamline liquid handling workflows in protein crystallography drop setting and beyond while enhancing research quality and productivity. 

mosquito Xtal3 delivers protein crystallization without compromise. 

SAXSpace is a new nanostructure analyzer for small- and wide-angle X-ray scattering (SWAXS) studies of nanostructured materials. With its easy handling and push-button alignment, SAXSpace is ideally suited for routine SWAXS analysis and quality control applications. SAXS experts benefit from the spacious sample chamber and versatile sample stages, allowing for full experimental flexibility. This makes SAXSpace an ideal tool fo…

The Freedom EVO Protein Crystallography workstation is a highly flexible, fully scalable liquid handling platform that can be configured for semi- or complete automation protein crystallography experiments.

Harnessing innovative positive displacement pipetting to simplify protein crystal optimization 

The worlds fastest and most sensitive CCD detector           The Eos CCD is the fastest and most sensitive CCD detector for X-ray diffraction from Agilent or any manufacturer. With an active area of 92 mm diagonal and a gain of 330 e-/X-ray (Mo) the Eos is the highest sensitivity CCD detector available today. It is ideal for the most challenging experiments in small molecule crystallography, providing data collections faster…

Trypsin is a serine protease that specifically cleaves at the carboxylic side of lysine and arginine residues.   The stringent specificity of trypsin is essential for protein identification. Native trypsin is subject to autolysis, generating pseudotrypsin, which exhibits a broadened specificity including a chymotrypsin-like activity. Such autolysis products, present in a trypsin preparation, would result in addition…

ProteaseMax™ Surfactant is a high-quality reagent for use in protein and peptide sample preparation.   ProteaseMax™ Surfactant solubilizes proteins and ensures fast and improved protein digestion with trypsin or chymotrypsin. It is designed to degrade over the course of a digestion reaction, yielding products that are compatible with downstream methods such as mass spectrometry (MS) and liquid chromatography (LC). For…

Fluorescence Recovery After Photobleaching

Reliable Drop Setting: Reduce Costs + Increase Reproducibility The NT8 ® - Drop Setter/Crystallization Robot is a fast, nanoliter-volume liquid handler with drop dispensing capability, including setting drops for Lipidic Cubic Phase (LCP) experiments. The 8-tip head aspirates and dispenses drops from 10 nL to 1.5 μL.

Remove the guesswork. SONICC ® finds protein crystals that other technologies cannot. The ultimate imaging technology in visualizing protein crystals, Second Order Nonlinear Imaging of Chiral Crystals (SONICC) definitively finds crystals buried in precipitate or submicron crystals naked to the eye. 

Crystal Clear Imaging. Unparalleled Speed. ROCK IMAGER ® - Crystallization Imagers are a series of automated imaging systems designed for protein crystallization screening. Capture superior quality images of your protein drops while learning critical information about your crystals. ROCK IMAGERs are available with various plate capacities and imaging features, so there is a model to fit every lab's budget and workflow.

One Software for Your Entire Protein Crystallization Workflow One protein crystallization software to manage the entire experimentation process, from design and dispense to image viewing and analysis. ROCK MAKER® is a Laboratory Information Management System (LIMS) that is there every step of the way, with powerful yet easy-to-use tools that help you get the results you need quickly.  

Build Crystallization Screens with Ease The FORMULATOR ® - Screen Builder is a next-generation liquid handler specifically designed for Protein Crystallography that uses patented microfluidic technology to dispense up to 34 different ingredients to design even the most complex optimization screens. A 96-nozzle dispensing chip can dispense any volume of any ingredient of any viscosity into any well.

Highly accurate micro area residual stress with both iso- and side-inclination methods. In the past, if you wanted to make highly accurate residual stress measurements, you had to use an R&D diffractometer because of the accuracy of the goniometer. However this restricts the weight and size of the samples you can measure. On the other hand, dedicated laboratory and factory-floor residual stress analyzers suffer from reduced a…

The MicroMax-003 is a third generation microfocus sealed tube X-ray generator for X-ray diffraction and crystallography. It is the perfect X-ray source for someone who wants the benefits of a microfocus X-ray source (low power consumption and long tube life) without the added maintenance that goes along with a more powerful rotating anode microfocus X-ray source.It consists of a tightly coupled microfocus generator and specia…

The Crystal Screen and Crystal Screen 2 reagent kits are designed to provide a highly effective and rapid screening method for the crystallization of macromolecules. The screens are simple and practical for finding initial crystallization conditions. The initial crystallization conditions for more than 1,000 proteins, peptides, oligonucleotides, and small molecules have been determined using Crystal Screen.A highly effective…

Originally published in 1991 by Jancarik & Kim from conditions found to be successful in the crystallization of biological macromolecules. This classic standard sparse matrix screen lets you: Determine initial crystallization conditions. Establish the solubility of a macromolecule in a varying range of pH and precipitants. and with the enhanced buffer selection enables screening of greater crystallization space.Structure Scre…

The PCT Pre-Crystallization Test is used to determine the appropriate protein concentration for crystallization screening. Sample concentration is a significant crystallization variable. Samples too concentrated can result in amorphous precipitate, while samples too dilute can result in clear drops. Precipitate and clear drops are typical crystallization screen results for reagent conditions which do not promote crystallizati…

PEG/Ion, developed by Hampton Research, is a crystallization screen designed to evaluate monodisperse, high purity Polyethylene glycol 3,350 and 48 unique salts representing a very complete range of anions and cations frequently used in the crystallization of biological macromolecules. The primary screening variables are PEG, ion type, ionic strength, and pH. More than 60% of the published crystallizations utilized PEG as a p…

SaltRx was developed by Hampton Research as a primary and secondary, salt and pH based crystallization screen for biological macromolecules. Salt is the only primary crystallization reagent (precipitant) utilized. Based on a design of 96 conditions, the screen evaluates a broad portfolio of crystallization salts of varying concentration and pH.SaltRx can be used as a primary crystallization screen when salt, ionic strength an…

Index is designed as a 96 reagent crystallization screen that combines the strategies of the grid, sparse matrix, and incomplete factorial screening with traditional, contemporary, and new crystallization reagent systems into a highly effective and efficient format. Index, as the name implies, efficiently samples a series of specially formulated reagent zones to identify which reagent class or classes and pH are effective in…

Individual reagents from the Grid Screen Ammonium Sulfate and Grid Screen Salt HT screens. Grid Screen Ammonium Sulfate Individual Reagents Features: 185 ml volume Sterile filtered Applications: Individual Grid Screen Ammonium Sulfate and Grid Screen Salt HT screen reagents for screening, optimization and production

Grid Screen Salt HT combines Grid Screen Ammonium Sulfate, Grid Screen Sodium Malonate, Quik Screen and Grid Screen Sodium Chloride into a single 96 Deep Well block format. The block contains 1 ml of each reagent. Features: A systematic grid screen varying salt or polymer or organic versus pH Samples pH 4 to 9 Combine reagents within or between screens to customize your screen Combine reagents between rows or colum…