Nexera UC
Supercritical Fluid Extraction/Chromatograph System.
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The world’s first-ever unified and fully automated instrument combining supercritical fluid extraction (SFE) with supercritical fluid chromatography (SFC).
Shimadzu has released its new Nexera UC unified chromatography system. It is the world’s first-ever unified and fully automated instrument combining supercritical fluid extraction (SFE) with supercritical fluid chromatography (SFC). The SFE/SFC/MS platform merges quick and easy online sample preparation with advanced chromatographic analysis and high sensitivity detection. The Nexera UC serves a wide range of applications, e.g. monitoring of pesticides in food products, additives in polymers, drug discovery in pharmaceuticals and biopharmaceuticals and environmental controls or cleaning validation to name just a few.
Increasing speed and efficiency while reducing the risk of human error in the analytical workflow.
The Nexera UC online SFE-SFC approach eliminates the need for tedious, manual sample pretreatment. All samples are extracted under light-shielding, anaerobic conditions, enabling highly reproducible analysis even of unstable compounds that are easily oxidized or degraded using a conventional liquid extraction method. Notably, analysis of pesticides in food products, with the state-of-the-art Nexera UC system and sample preparation in the SFE unit takes just a fraction of the time needed using the traditional QuEChERS method. Furthermore, the fully automated Nexera UC system offers much higher recovery rates of target analytes while significantly reducing the risk of human error during sample pretreatment.
Nexera UC provides hassle-free, highly efficient sample extraction of up to 48 samples with easy on-line transfer to chromatographic separation and MS/MS detection. The system achieves the highest levels of sensitivity due to splitless injection of the entire eluent volume.
”Green” chromatography.
The innovative Nexera UC system offers a supplementary chromatographic technique to conventional LC and GC analysis that enables separation of an even wider range of non-polar to very polar analytes. Automated extraction and chromatography are achieved using a mobile phase of supercritical carbon dioxide, which exhibits the solubility of a liquid with the diffusivity of a gas. Solvent strength can be increased by adding a polar co-solvent. SFE and SFC are therefore faster, more efficient, cheaper and more environmentally friendly than other methods using large amounts of toxic organic solvents.
Features:
- Very fast separation speed due to the relatively low viscosity of supercritical fluid
- Improved peak capacity and chromatographic resolution
- Efficient separation of analogues and/or chiral compounds by high penetration mobile phase
- Different separation mode leads to high sensitivity
- Improved sensitivity resulting from split-less introduction into detector
- Reduction of environmental impacts and costs by reducing amount of organic solvents needed
Pfizer drives cancer research breakthroughs with supercritical fluid chromatography
Supercritical fluid chromatography (SFC) is a separation technique that uses a supercritical fluid (most commonly carbon dioxide) as the mobile phase to efficiently purify compounds, offering faster processing, lower solvent consumption, and a more environmentally friendly alternative to traditional liquid chromatography (LC) methods. In this SelectScience interview, Jeff Elleraas, Principal Scientist at Pfizer’s Global Research and Development in La Jolla, California, shares insights into the role of SFC and how machine learning and AI are transforming chiral separations. Plus, discover Pfizer’s mission to tackle the toughest challenges in oncology research, accelerate medicinal chemistry innovations, and create greener, more efficient processes for developing novel cancer treatments.
Find out more information on Nexera UC here: https://www.shimadzu.com/an/products/liquid-chromatography/sfc/nexera-uc/index.html
