Octet® SF3 SPR System
Octet® SF3 SPR - Powered and Prepared
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With exceptional sensitivity for both small and large molecules, low baseline noise and drift, large injection volumes and the novel OneStep® and NeXtStep™ Gradient Injection Technologies, the new Octet® SF3 allows users to generate high-quality kinetics and affinity data in a fraction of the time compared to standard multi-cycle kinetics (MCK). Combined with software designed by users for users, the Octet® SF3 offers a robust, high-throughput, low maintenance SPR solution for the rapid characterization of a wide variety of biomolecular interactions.
Assessment of small molecule kinetics and affinity using OneStep Injections in SPR screening
This application note explores how OneStep® injections on the Octet® SF3 SPR system revolutionize small molecule and fragment-based drug discovery. By enabling real-time kinetic and affinity analysis from a single injection, OneStep® eliminates the need for serial dilutions and multi-cycle assays, saving time, sample, and cost. Learn how this method delivers high-content data with minimal setup, allowing researchers to screen hundreds of compounds rapidly and confidently.
The power of in-line mixing for competitive compound analysis
This application note introduces NeXtStep™ injections on the Octet® SF3 SPR system, a powerful method for performing rapid, in-line mixing competition assays without the need for pre-mixed samples. Learn how this technique simplifies assay setup, reduces false positives, and enables accurate site-specific binding analysis. Featuring real-world examples with sulfonamides, the note demonstrates how NeXtStep™ enhances fragment screening and small molecule characterization with high sensitivity and efficiency.
