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Plenary Lecture: How Far Are We in the Chase after the Lowest Detectable Level for Dioxins?

Thermo Fisher Scientific
13 Oct 2015
Lois Manton-O'Byrne, PhD
Executive Editor

Industry news

The chase for sensitive dioxin measurement methods has been going on for the last few decades. It opened when chickens were dying from Chick edema disease in the US in 1957. Today, one can surely say that we have reached a state-of-the-art in that field. Currently GC-MS methods can routinely work at the low picogram-high femtogram level, based on the use of high end MS sector instruments, but also the last generation of triple quadrupole analyzers. The latter being recently accepted as a tool for confirmatory measurement in food and feed under the maximum level (ML)-based EU legislation.

Once we consider human biomonitoring, the situation is somewhat different as there are no ML set for humans. The challenge there is to be able to measure the lowest possible quantity of target analytes, in order for the toxicologist working downstream of the analytical chemist to be able to properly analyze the situation in terms of global toxicity. Large volume injections (LVI), cryogenic compression (CZC), better ion production and transfer, longer ion accumulation times, … are the possible ways to enhance signals and improve instrument limits of quantification (iLOQs). Proper monitoring of blank levels is also of prime importance when considering method LOQs (mLOQs) as laboratory background levels are quite independent of sample sizes when chasing at sub femtogram levels and can easily exceed the levels to be measured in samples.

This presentation will focus on recent advances in the field of measurement at ultra-trace levels of dioxins and related compounds in the frame work of human biomonitoring. More information here.

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Gas ChromatographyGas chromatography (GC) is an analytical technique used to separate and quantitate mixtures of small and volatile compounds. Gas chromatographs or GC systems include components such as GC columns, detectors, pumps and autosamplers. Choose from packed or capillary GC columns, flame ionization (FID), photoionization (PID) electron capture detectors and selective or non-selective detectors. Find the best gas chromatographs in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Environmental Monitoring and TestingEnvironmental monitoring and testing uses handheld portable analyzers, kits, spectrometers or chromatography systems for air, water, soil, food and other sample testing. Useful features of analyzers such as BOD and COD include portability, easy calibration, automation and sensitivity.  Environmental test kits for pH, water, moisture, etc, should be accurate, sensitive, reliable, fast and easy to use.Food and Beverage AnalyzersFood and Beverage Analyzers are commonly used to provide information about the chemical composition, structure and physical properties of food materials.Food and Beverage ProcessingFood and Beverage Processing involves the preparation of food products for further analysis. Typical instrumentation includes blanchers, color sorters, cookers, grinders, and refrigeration. These are used to replicate the processes commonly used in the commercial preparation of food and beverages.GC-MS GC-MS (gas chromatography-mass spectrometry) instruments and equipment are used to separate, quantify and identify mixtures of small and volatile compounds, such as polycyclic aromatics, fatty acids and alcohols. Often used in drug detection, forensic investigation and environmental analysis for pesticides and contaminants, GC-MS is a powerful addition to your lab’s analytical capabilities. GC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzers can give greater sensitivity and resolution to your analysis. Find the best GC-MS instruments and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Toxicology / Drugs of Abuse TestingToxicology and Drugs of Abuse Testing is the investigation into toxic and illegal substances found at the scene of a crime or from a suspect and / or victim associated with a scene of a crime. Analyzers, immunoassays and drugs of abuse test kits and presumptive test kits are an essential aspect of toxicology investigation.Food SafetyFood safety describes the prevention of food-borne illnesses. Contamination with a variety of pathogens can be prevented with adequate temperature control, hygiene and labeling. Food samples can be tested using GC/MS, HPLC, SPE, and qPCR to ensure their adherence to regulations.Food TestingFood testing refers to a variety experiments including PCR, mass spectrometry, processing, QuEChERS, analyzing and Kjeldahl.Trace Level ImpuritiesTrace level impurities refer to low concentrations of unwanted substances found in chemicals, pharmaceuticals, and other products. Detecting and removing these impurities is crucial for product safety and regulatory compliance. Explore trace impurity analysis tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Environmental ContaminationContaminants in the environment are harmful chemicals that are present in the air, land and water. These include pesticides, pharmaceuticals, persistent organic pollutants (POPs) and many more.DioxinsDioxins are a group of persistent environmental pollutants (POPs) that comprise of chlorinated organic chemicals. These airborne particles can deposit on plants or in water, and animals can accumulate these highly toxic molecules in their fat.PesticidesPesticides are used to protect crops from diseases, pests and unwanted plants. They are classed as persistent organic pollutants (POPs) and can be harmful to humans. The Environmental Protection Agency (EPA) currently regulates the use of pesticides in the USA.

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Plenary Lecture: How Far Are We in the Chase after the Lowest Detectable Level for Dioxins?