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Optimizing cell culture and analysis using LC-MS

5 Feb 2025
Optimizing cell culture and analysis using LC-MS

The biopharmaceutical market is rapidly growing with new therapeutics and biosimilars. Contributing to this growth is the development of therapeutic monoclonal antibodies to treat a variety of serious diseases. The increased interest in biologics has resulted in significant growth in the cell cultures market. Ensuring that the cultural media mix is optimal for cell growth is vital to drug development and the quality of the final product. Hear how technological advancements like LC-MS improve analysis accuracy, aid in the production of monoclonal antibodies and ensure quality in biosimilars and stem cell research.

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Shimadzu Corporation

Shimadzu Corporation was founded in Kyoto, Japan in 1875 and has been supplying cutting-edge analytical and measuring instruments for a broad range of applications for over 140 years. Key markets include pharmaceuticals, life sciences, food & beverages, chemicals, petrochemicals, environmental, material science, and forensics/toxicology. Products include chromatographs (HPLC/UHPLC/SFC, GC), mass spectrometers (GC-MS/MS, LC-MS/MS, MALDI, ICP-MS), spectrophotometers (FT-IR, Fluorescence, UV-VIS-NIR), atomic spectrometers (AA, ICP), X-ray spectrometers (ED-XRF, XRD, XRF), thermal analyzers, Total Organic Carbon (TOC) analyzers, particle size analyzers, material testing machines, and balances, etc.

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Monoclonal AntibodiesMonoclonal antibodies (mAbs) are lab-made molecules that can bind to specific antigens on cells, making them highly effective in treating cancers, autoimmune diseases, and infections. These targeted therapies are transforming the treatment landscape for many conditions. Browse our peer-reviewed product directory to find monoclonal antibodies for research and clinical applications; compare products, check reviews, and get pricing directly from manufacturers.