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Exploring cell-free DNA and small RNA analysis techniques

12 Jun 2025
Exploring cell-free DNA and small RNA analysis techniques

Discover how you can sensitively determine sample quality using the Bioanalyzer, TapeStation and Fragment Analyzer from Agilent Technologies. These automated electrophoresis systems can be used for cell-free DNA (cfDNA) and small RNA quality control and analysis. Delivering highly accurate and precise analytical evaluation, learn how these systems fit perfectly into next-generation sequencing (NGS), biobank or vaccine development workflows for low to high sample throughput.

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Agilent Technologies

Agilent is a leader in life sciences, diagnostics, and applied chemical markets.

The company provides laboratories worldwide with instruments, services, consumables, applications, and expertise enabling customers to gain the insights they seek. Agilent’s expertise, innovative technology solutions, and trusted collaboration gives them the highest confidence in our solutions.

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4200 TapeStation Instrument

Agilent Technologies

The Agilent 4200 TapeStation system is an established automated electrophoresis tool for DNA and RNA sample quality control. Fully automated sample processing enables the unattended analysis of size, concentration and integrity. Choose any sample number between 1 and 96 and analyze at constant cost per sample.

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4150 TapeStation system

Agilent Technologies

The 4150 TapeStation system is an economic, entry-level system which comes with data processing software, reagents, and ScreenTape devices for analysis of sample size, quantity, and integrity of 1 to 16 samples. Delivering highly accurate and precise analytical evaluation, the systems fit perfectly into next-generation sequencing (NGS) or biobank workflows for handling smaller numbers of samples.

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Bioanalyzer RNA Kits & Reagents

Agilent Technologies

The Agilent RNA kits with the patented RNA Integrity Number (RIN) are the industry standard for RNA quality assessment. Do fast, easy and precise integrity checks and sample quantitation before any RNA dependent application.Maximum flexibility check the quality of your total RNA, mRNA, or cRNA samples Minimal sample consumption use as little as 5 ng of total RNA or 50 pg of total RNA for analysis, saving most of your valuable preps RNA Integrity Number (RIN) a reliable tool to compare integrity of RNA samples automatically plus freely accessible RNA Integrity Database (RINdb) a freely accessible repository holding hundreds of user submitted total RNA traces RNase free use RNase free reagents and chips to avoid sample degradation during analysis Ready-to-use - standardized assays and pre-packaged reagent kits Faster results analyze 11 to 12 samples in 30 minutes

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DNA / RNA Extraction and PurificationPurified DNA and RNA are required for numerous downstream molecular biology applications. Consequently, the importance of high-quality DNA/RNA extraction and purification equipment cannot be underestimated. Many purification kits are available and are typically optimized for nucleic acid type and source, including plasmid DNA, genomic DNA, mRNA, RNA and viral nucleic acid purification kits. Automated extraction and purification of nucleic acids can be implemented with magnetic bead separator instruments or high-throughput purification workstations. Find the best DNA/RNA extraction and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Quality ControlQuality control is needed in all production processes. Quality control is a monitoring procedure or set of procedures that are put in place to ensure that a manufactured product adheres to a defined set of quality criteria. cfDNARNARNA is a nucleic acid that plays a key role in gene expression and protein synthesis. It serves as a messenger between DNA and ribosomes, carrying genetic instructions to produce proteins. Advances in RNA-based therapies, such as mRNA vaccines and gene editing, have revolutionized treatment strategies for genetic disorders and infectious diseases. Explore RNA research tools and therapies in our peer-reviewed product directory; compare products, check customer reviews, and get pricing directly from manufacturers.