Combining orthogonal glycan analysis techniques for a deeper understanding of a tri-specific protein
6 Feb 2025
Explore the critical role of glycosylation in multispecific proteins and its impact on their function. Michael McKinnon, from Novartis Institutes for Biomedical Research, highlights traditional glycosylation analysis methods and presents a case study on a TriSpecific fusion protein, emphasizing the need for precise glycan localization. The discussion compares Electron-Activated Dissociation (EAD) and Collision-Induced Dissociation (CID) techniques, showcasing their applications in glycan analysis. The ZenoTof 7600 is introduced as a powerful tool for advanced protein characterization, providing deeper insights into glycan structures and modifications.
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SCIEX
SCIEX helps to improve the world we live in by enabling scientists and laboratory analysts to find answers to the complex analytical challenges they face. The company's global leadership and world-class service and support in the capillary electrophoresis and liquid chromatography-mass spectrometry industry have made it a trusted partner to thousands of the scientists and lab analysts worldwide who are focused on basic research, drug discovery and development, food and environmental testing, forensics and clinical research. With over 40 years of proven innovation, SCIEX excels by listening to and understanding the ever-evolving needs of its customers to develop reliable, sensitive and intuitive solutions that continue to redefine what is achievable in routine and complex analysis.
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