Phenomenex Pharmaceutical Analysis Brochure

29 Jun 2016

This brochure provides information on how Phenomenex products can help you achieve resolution, ruggedness and reproducibility in your formulations assays.

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Yarra Ultra-High Efficiency Aqueous GFC/SEC Columns
Phenomenex Inc
Starting with 3 µm ultra-pure silica, Yarra particles are densely bonded with a proprietary surface chemistry. Coupled with tight particle and pore size distribution as well as strict packing and QC specifications, Yarra GFC columns allow for the highest efficiencies and resolution possible. Yarra columns are offered in three phases (SEC-2000, 3000, and 4000), and are ideal for the separation of small to large proteins, as well as biological therapeutics and biosimilars.
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Kinetex Core-Shell HPLC/UHPLC Columns
Phenomenex Inc
The Core-Shell Advantage
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Zebron GC Columns
Phenomenex Inc
Ensure accurate and reproducible results in your GC-MS analyses
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Zebron™ ZB-624 GC Columns
Phenomenex Inc
Robust Results for VOCs and Residual SolventsIncreased temperature limit speeds run times and re-equilibrationPopular choice for residual solvent testing (USP Monograph )Widely used to separate volatile organic flavor and fragrance additives and residual solvents in industrial or pharmaceutical products (OVIs)Equivalent to USP phase G43Recommended UseEPA Methods (501.3, 502.2, 503.1, 524.2, 601, 602, 624, 8010, 8015, 8020, 8021, 8240, 8260), Pharmaceuticals, Residual Solvents, Volatile Organic Compounds (VOCs)
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Rezex Organic Acid and Carbohydrate Columns
Phenomenex Inc
Rezex™ columns achieve separations based on multiple modes of interaction including ion-exchange, ion-exclusion, size exclusion, reversed phase, and partition. From drug formulation analysis to quality control testing of finished food products, to bioethanol fermentation monitoring Rezex columns consistently provide accurate and reproducible results.Choose Rezex for excellent resolution and reproducibility of sugars, starches, alcohols, organic acids, and oligonucleotides.Available in a wide range of ionic selectivities (Na+, Ca+2, Pb+, Ag+, and more). Guaranteed alternative to Bio-Rad® Aminex®.
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Aeris Core-Shell LC Columns for Proteins and Peptides
Phenomenex Inc
Core-Shell Particles Precision Engineered for Protein and Peptide Separations. Core-shell particle technology provides striking increases in peak capacity and resolution at lower backpressure, giving chromatographers the ability to achieve ultra-high performance on ANY system, HPLC or UHPLC. A uniform porous silica layer is grown around a solid, spherical silica core, providing effective retention and selectivity with improved resolution, speed, and recovery. Next, optimizing the pore size and shell thickness for intact proteins or smaller peptide fragments provides well-defined depth penetration of biomolecules leading to maximum separation power. Column Specifications: Phase: PEPTIDE XB-C18, WIDEPORE C4, WIDEPORE XB-C18, WIDEPORE XB-C8 Particle Size: 1.7, 2.6, 3.6, 5.0 µm Pore Size: 200, 100 Å Length: 50, 100, 150, 250 mm ID: 2.1, 3.0, 4.6, 10.0, 21.2 PEPTIDE XB-C18 Synthetic peptide impurity analysis Peptide mapping Identifying protein modifications - Glycosylation - Substitution - Truncation Analyzing post-translational modifications - Deamidation - Oxidation - Deletions WIDEPORE XB-C18 Proteins Hydrophilic proteins PEGylated proteins High temperature separations Alternative selectivity for peptide mapping WIDEPORE XB-C8 Large proteins Moderately hydrophobic proteins Monoclonal antibodies Glycosylated proteins High temperature separations WIDEPORE C4 Very large proteins Very hydrophobic proteins Membrane proteins Least retentive
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Zebron™ ZB-WAXplus GC Columns
Phenomenex Inc
100% Aqueous Stability for Polar Compounds100% aqueous stable, excellent for aqueous samples; bonded and solvent rinseableExtremely inert for acidic compoundsEnhanced selectivity for low boiling solvents; high retention of alcohols and chlorinated solventsIncreased efficiency at 20 °CZB-WAXplus provides optimal selectivity for many aqueous soluble compounds such as those found in alcoholic beverages or glycol samples. The ZB-WAXplus bonding process results in exceptional stability to repeated injections of aqueous matrices like whiskey. Multiple or routine water injections will not alter the efficiency or polarity of the phase over time.Recommended UseAlcohols, Aldehydes, Aromatics, Essential Oils, Flavors & Fragrances, Free Fatty Acids, Glycols, OVIs, Pharmaceuticals, Solvents / Residual Solvents, Styrene, Xylene IsomersEnhanced Aqueous Stability
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Gemini pH Flexible LC Columns
Phenomenex Inc
Setting the Standard for pH Method DevelopmentRugged reversed phase HPLC columns that offer extended lifetime under extreme pH conditions and excellent stability for reproducible, high efficiency separations. Take full advantage of high and low pH conditions (pH 1-12) to manipulate selectivity Expect longer column lifetime with patented TWIN-NX™ technology Ideal for analytical and preparative separations of basic and acidic compounds Who needs Phenomenex's Gemini HPLC columns? Method Developers: Extreme pH method flexibility Reproducible performance Purification Chemists: Purify bases at high pH Increased loading Increased retention Increased resolution Lab Managers: Extended column lifetime Consistent results.
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Synergi Full Range Selectivity LC Columns
Phenomenex Inc
Full Range SelectivityFour unique phases developed to provide a different selectivity for successful separations of the most complex mixtures and challenging analytes under reversed phase conditions. Whether your compounds are hydrphobic or polar, Synergi columns provide you with a full range of selectivity, ensuring separation of the most challenging and complex mixtures.
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Phenogel™Organic GPC/SEC Columns
Phenomenex Inc
Phenogel™ Gel Permeation Chromatography Columns for size exclusion are available in seven different pore sizes ranging from 50 Å to 10 6 Å, and a linear bed configuration. Pore size distribution and pore volume are closely controlled parameters in the manufacturing process, accounting for high resolution, tight linear calibration curves and excellent column-to-column reproducibility.Phenogel GPC columns offer high cross-linkage for mechanical and chemical stability, and temperature stability for 140 °C and 240 °C. Phenogel columns are available in 5, 10, and 20 µm particle sizes. Column dimensions range from narrow bore solvent saver (4.6 mm ID) to preparative (21.2 mm ID).Available in high resolution pore sizes and linear configurations.
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Onyx Monolithic LC Columns
Phenomenex Inc
Acheive Faster HPLCOnyx monolithic silica-based HPLC columns are designed for high-throughput analysis and the direct injection of dirty or viscous samples. Reduce run times with extremely high flow rates (up to 9 mL/min) "Dilute-and-Shoot” dirty biological samples Scalable from capillary to semi-prep column dimensions Onyx columns deliver high efficiency separations and can be coupled together in series to produce the extreme plate counts needed to separate very complex mixtures.Dilute & Shoot Complex mixtures coupled with dirty matrices, such as serum samples encountered in the pharmaceutical/biotechnology industry, are quite difficult and time-consuming to analyze. With Onyx however, you have the option to dilute-and-shoot your sample directly onto the column because it won't clog due to the macroporous system or cause high backpressures. Flow Rate Flexibility Another unique feature is the ability to use flow rate as parameter for optimizing separations. Onyx columns are responsive to changes in flow rate and can be changed mid run to reduce total run time when certain compounds elute much later. This type of flow rate flexibility gives many options for optimization.
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