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Improve triage with FAM19A4/miR124-2 methylation analysis

Fujirebio
6 May 2024

The transition to high-risk human papillomavirus (hrHPV) testing as the primary screening method for cervical cancer is gaining traction worldwide due to its objectivity, high throughput, and superior sensitivity compared to cytology. However, distinguishing clinically relevant infections from transient ones remains a challenge, leading to higher rates of unnecessary colposcopy referrals. Triage methods for hrHPV-positive women must balance high sensitivity, specificity, and predictive values while minimizing additional sample requirements and patient burden. Various approaches, including DNA methylation analysis, are being explored to improve triage accuracy and efficiency. Fujirebio highlights FAM19A4/miR124-2 methylation analysis as a promising method with high sensitivity, specificity, and long-term safety, offering potential as an alternative to cytology for hrHPV-positive women.

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High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.MethylationAssay DevelopmentThe process of proving an assay to be sensitive with respect to the target is known as assay development. The assay should be able to characterize novel compounds and measure the potency of these compounds against a validated biological target.ScreeningUsing robotics, data processing and control software, liquid handling devices and sensitive detectors, screening allows a researcher to quickly conduct millions of chemical, genetic or pharmacological tests.Cancer ResearchAlthough cancer is often referred to as a single condition, it actually consists of more than 100 different diseases. Microscopy, mass spectrometry, high throughput sequencing and flow cytometry are some of the most common techniques employed in cancer research labs.

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Improve triage with FAM19A4/miR124-2 methylation analysis