Care for pregnant women with precancerous cervical lesions

Cervical cancer is increasingly diagnosed during pregnancy, with the highest incidence of high-grade intraepithelial lesions (HSILs) occurring in women aged 25–35. Despite varying data on the regression, persistence, and progression of cervical intraepithelial neoplasia (CIN) during pregnancy, progression to invasive carcinoma is rare, justifying a wait-and-see approach with postpartum follow-up and treatment as necessary. Management of CIN during pregnancy has shifted towards a more conservative approach, yet challenges persist due to subjective cytology and the complexity of interpreting results during pregnancy. Fujirebio highlights improved triage markers, such as FAM19A4/miR124-2 methylation, offering promise in predicting the course of CIN lesions in pregnant women, aiding in safer management until after delivery.