Scale-up > Scale-up Equipment Products & Reviews

The NucleoCounter® NC-202™ automated cell counter is our 3rd generation cassette-based image cytometer. Featuring improved hardware and new NC-View™ software, we take precision, speed and data management to new levels.

NucleoCounter® instruments provide platforms for determination of viability and cell count as well as advanced image analysis of yeast, veterinary semen, insect cells and mammalian cells, both primary cells and cell cultures, including cells in aggregate or microcarrier cultures.

The NucleoCounter® NC-3000™ is an advanced image cytometer utilizing fluorescence imaging to characterize cell properties. The NC-3000™ can perform high-speed cell count and viability analyses and it includes plug-and-play analytical assays of mammalian, yeast and insect cells. Pre-defined assays include a unique 5-minute cell cycle assay, a selection of apoptosis assays and a GFP transfection efficiency assay.

DASGIP Parallel Bioreactor Systems for R&D and process development in both cell culture and microbiology allow for advanced bioprocess control and automation. Parallel processing, precise control of all relevant parameters, user-defined profiles and innumerable automation features result in accelerated and highly efficient process development. Our DASware software solutions support DoE, process historians and comprehensive…

Recombinant, expressed in Pichia pastoris, ATPase ≥1000 units/mg protein, lyophilized powder.

3M™ Harvest RC Centrate Chromatographic Clarifier is a single stage single-use chromatographic clarification solution designed to effectively clarify modern cell culture centrates. Centrate clarification using 3M™ Harvest RC Centrate Chromatographic Clarifier may provide many benefits including process compression, high product recovery, and improved process economics.

The 3M™ Harvest RC Chromatographic Clarifier is a single stage single-use chromatographic clarification solution designed as an efficient option for harvesting and clarification of modern cell cultures. Clarification using 3M™ Harvest RC Chromatographic Clarifier may provide many benefits including fewer processing steps, higher yield and lower production time and costs.

ProVance™ columns are a high-performance disposable chromatography solution to help meet the growing demand for downstream purification. Until now, there has not been a cost-effective Protein A chromatography option for single-use manufacturing facilities. ProVance™ columns combine Grace proprietary incompressible silica with cost-effective Protein A and disposable column hardware.Grace is the world's largest supplier of spec…

A micro-well, plate-based multi-channel bright field and 4 fluorescent channels imaging cytometer for 2D and 3D culture using both adherent and suspension cells.

A micro-well, plate-based bright field imaging cytometer for 2D and 3D culture using both adherent and suspension cells.

A micro-well, plate-based multi-channel bright field and 3 fluorescent channels imaging cytometer for 2D and 3D culture using both adherent and suspension cells.

Chemical process safety by design.

Improve reaction understanding with real-time in situ analysis.

Unattended, representative sampling for a wide range of chemical reactions.

Reaction and process understanding with real-time in situ analysis.

Access crystallization and formulation information at mL scale with the new Crystalline PV/RR

From laboratory to pilot scale, YMC offers reliable, high quality glass columns for all kind of application areas.

YMC PilotPLUS columns are completely biocompatible and characterised by safe and easy handling.

Does your application require customised pilot columns? With YMC Pilot columns, customised versions can be constructed to address your needs. Of course standard dimensions are available, too!

Advanced crossflow (AXF) mixing has solved the problem of how to efficiently create the highest quality micro and nano-spheres, emulsions, and crystals around a chosen size with a robust, cost-effective, scalable technology.

Our engineers designed the rCPC platform for pilot-scale purification tasks within a laboratory environment. It is ideal for all batch sizes, smaller or larger, or campaign type of research work, and continuous-batch production. To accommodate a user-friendly operation, RotaChrom offers a turn-key solution package for semi-automated solvent handling (preparation and recovery) upon request. rCPC can be utilized as an at-line p…

RotaChrom’s iCPC platform is the largest commercially available Centrifugal Partition Chromatography instrument in the world. Designed for industrial-scale purification projects in continuous batch operation mode, this device is by far the most cost-effective industrial-scale chromatography platform available on the market. It has the capacity to process hundreds of kilograms of crude input material per month.The iCPC uses si…

The pCPC is a tailor-made system by RotaChrom. It is a combination of the iCPC and a solvent preparation, recovery and regeneration system. It also delivers a proprietary automated biphasic solvent system preparation platform, providing a continuous feed to our iCPC instrument.pCPC encompasses a fully integrated production platform where complete solvent handling is provided beside the iCPC’s purification solutions. The syste…

Add even more to your production with pCPC combined with the Heivap platform. This is a complex solution which enables complete solvent handling and allows the elimination of solvents and final polish of the product. The strategic partnership RotaChrom entered into with Heidolph comes with the possibility to combine the pCPC with Heidolph Heivap platform.  The scaled-up and extended system provides a versatile solution, while…

The Phi-TEC I is an adiabatic calorimeter that enables the characterization of thermal runaway hazards during process development and scale-up. The Phi-TEC I replicates industrial (large volume) conditions on a lab-scale, enabling thermal runaway hazards to be characterized safely and efficiently.