Gene Expression and Molecular Cloning Products & Reviews

For transient gene repression with CRISPR-level specificity

Horizon's CRISPRi guide RNA in an easy to deliver lentiviral format

Horizon's proprietary dCas9-SALL1-SDS3 CRISPRi repressor in mRNA format

Horizon's proprietary dCas9-SALL1-SDS3 CRISPRi repressor in lentiviral particle format

A direct and efficient set of tools to study a gene’s function by transcriptional interference in its native context

PD-L2/TCR Activator Mammalian Expression Kit

SU10 is a nanopipette-based tool for efficient and controlled delivery of material (such as CRISPR Cas9 complex, RNA, proteins) into the nucleus or cytoplasm of single cells in a highly automated manner. The CRISPR Cas9 complex can be delivered directly into the nucleus of a specific target cell in a minimally invasive manner through the utilized glass pipette in nanometer range (approx.100 nm).

25 x 20 µl reactions; kit includes 400 µl Reliance Select 5X reaction mix, 25 µl Reliance reverse transcriptase, Reliance Select random primers, oligo(dT), DNase and buffer, nuclease-free water

100 x 20 µl reactions; kit includes 400 µl Reliance Select 5X reaction mix, 100 µl Reliance reverse transcriptase, Reliance Select random primers, oligo(dT), DNase and buffer, nuclease-free water  

500 x 20 µl reactions; bundle of 5 boxes of 100 reaction kit; includes 2,000 µl Reliance Select 5X reaction mix, 500 µl Reliance reverse transcriptase, Reliance Select random primers, oligo(dT), DNase and buffer, nuclease-free water  

Lentivirus Gene Expression Vector

Nuclease-independent applications of CRISPR provide equal targeting specificity but instead of cutting, CRISPRi allows for targeted interference of gene function by delivering transcriptional repressor domains to a specific target sequence using modified dCas9 + gRNA complexes. Gene knockdown is complementary to CRISPR-KO and CRISPRa (activation) and has distinct advantages over existing loss-of-function strategies like RNAi.…

A push-button, benchtop biofoundry

Enables the direct capture and quantitation of different serotypes of AAV in crude lysates, column eluates, cell lysates and cell culture supernatants using the CaptureSelect™ anti-AAVX ligand. Total AAV capsid is determined by this quantitation technique.

GMP-manufactured Cas9 protein for clinical research

Next-generation CRISPR Cas9 protein engineered to deliver maximum editing efficiency

The next generation of RNP reagents

ClonExpress ® technology is a simple, fast and efficient DNA seamless cloning technology, which can clone the insert into any position of any vector. 

All-in-one, ready-to-use Cas9 and guide RNA (gRNA) expression plasmids for use with monocots and dicots.

CRISPR/Cas9-mediated recombineering is the most powerful bacterial genome engineering method to date. In addition, Cas9-mediated recombineering overcomes the dependence on a second recombination step, avoids the creation of destabilizing scar sites, can be used in multiplexing, and is less time-consuming than previous protocols.

This Lentiviral Packaging Mix is an optimized formulation of two plasmids expressing the key HIV packaging genes and a heterologous viral envelope gene.

Universal negative control CRISPRs have been designed not to recognize any sequence in the human, mouse or rat genome. 

Compare and contrast the features of a wide variety of guide RNA (gRNA) and Cas9 products for in vitro and in vivo CRISPR experiments. Select the best formats for your mammalian or plant applications: SygRNA ® synthetic gRNA, plasmid DNA, lentiviral particles, and proteins.

Exclusive human or mouse whole genome arrayed libraries developed with the Wellcome Sanger institute

Pooled CRISPR screening with 10x Genomics compatibility