Merck Drug discovery > Pre-Clinical Development Products & Reviews

Millipore’s FlowCellect™ DNA Damage (ATM) and Cell Cycle Analysis Kit is designed to identify the linkage between DNA damage in relation to cell cycle checkpoints in flow cytometry applications. The kit includes a directly conjugated Anti-phospho-ATM (Ser1981) Alexa Fluor® 488 conjugate plus a DNA dye (Propidium Iodide) which allows the researcher to perform bivariate analysis to identify where DNA damage takes place relativ…

Millipore’s FlowCellect™ Bivariate Cell Cycle Kit for DNA Replication Analysis is designed to investigate cells undergoing replication in S-phase of the cell cycle with high accuracy and confidence in flow cytometry applications. The kit includes a directly conjugated Anti-BrdU Alexa Fluor® 488 conjugate plus a DNA dye (Propidium Iodide) which allows the researcher to perform bivariate analysis to distinguish cells in two dim…

Millipore’s FlowCellect™ Bivariate Cell Cycle Kit for G2/M Analysis is designed to allow the researcher to easily identify, discriminate, and quantitate cells between the G2 and M-phases of the cell cycle. The kit can be used to perform bivariate analysis to measure cell cycle distributions by discrimination of cell cycle phases without the need of sophisticated software modules or algorithms. Having the ability to distingui…

Millipore’s FlowCellect™ Multi-Color DNA Damage Response Kit is designed to enable a researcher a quick and easy way to detect the phosphorylation state of ATM, SMC1 and Histone H2A.X by flow cytometry. Millipore’s FlowCellect™ Multi-Color DNA Damage Response Kit was developed and tested using the DNA damaging reagent, Etoposide, in HeLa cells as a model system but the kit can be used with other human cell lines to determine…

AFS 10E and 15E Systems provide an economical and reliable water purification solution for analyzers with pure water needs up to 300 L daily. AFS E systems combine state-of-the-art Elix electrodeionization (EDI) technology with other complementary water purification techniques to provide reliable and consistent water quality. Water produced by the systems complies with the Clinical and Laboratory Standards Institute (CLSI) gui…

Created specifically for solid dosage forms, Parteck® excipients are distinguished by outstanding functionalities and a unique particle structure. All Parteck® products are developed under our Functional Particle Engineering concept comprising advanced EMD Millipore technologies for quite extraordinary functionally relevant particle properties. These properties of Parteck® excipients offer decisive advantages to the formulato…

Registering an API is complex and thus very time-consuming. That’s why we’ve offer EMPROVE® api: high-quality raw materials for use as active pharmaceutical ingredients. EMPROVE® api raw materials are produced according to cGMP guideline ICH Q7. What’s more, all of our EMPROVE® API production plants are located in Western Europe and follow current environmental standards. And in order to support your products’ compliance with…

Raw material qualification is a key factor in assuring the quality and safety of biopharmaceuticals. Even still, performing tests and compiling required documentation on your own is costly and time-consuming. Enter EMPROVE® bio raw materials – your solution for getting products to market faster. EMPROVE® bio raw materials for use in biopharmaceutical production offer specifications adapted for use in upstream or downstream pr…

EMPROVE® exp for use as excipient As drug approval procedures grow stricter, regulatory requirements are becoming more demanding for excipients. Our high-quality EMPROVE® exp raw materials for use as excipients not only comply with relevant regulations, but also come with detailed documentation, facilitating lower costs of qualification, so you can get to market faster. EMPROVE® exp dossiers comprise information on the manuf…

Excellent hardness and fast disintegration for wet granulation formulations Mannitol, a sugar alcohol that predominantly occurs in three crystalline forms (alpha, beta and delta polymorph), is especially suitable as an excipient for advanced, highly active APIs thanks to its non-hygroscopicity and low content of reducing sugars. However, standard mannitol (in beta quality) often lacks sufficient binding and compaction propert…

With today’s faster, leaner production requirements, the smooth integration of pharmaceutical excipients is essential. And since pharmacopeia now specify functionality in addition to chemical purity, Merck Millipore has adopted these challenges in a new addition to the Parteck® family. Parteck® LUB products are vegetable grades of Magnesium stearate, Calcium stearate and Stearic acid, the most effective excipients for lubrica…

Advanced technology for excellent tabletting properties Mannitol is a sugar alcohol that is especially suitable as an excipient for advanced, highly active APIs due to its non-hygroscopicity and low content of reducing sugars. Merck Millipore's outstanding, directly compressible mannitol Parteck® M is your best choice – especially if your tableting aims at rapid release of high-dose or low-dose actives.Parteck® M belongs to t…

Parteck® Mg DC – directly compressible without additives The efficient and safe production of tablets – from drugs to fizzy tablets – requires high-quality excipients, especially if higher ingredient concentrations are needed. The best choice for formulation of such drugs are excipients that are directly compressible because they make it possible to produce sufficiently hard tablets at high quality and with fewer process step…

Merck Millipore’s Parteck® ODT gives formulators the opportunity to produce top-quality, rapid-acting tablets more cost-effectively than ever. These days, people want no-fuss, no-wait solutions – convenience products that work, quickly and without hassle. This is why many patients prefer orally disintegrating tablets, or ODTs.ODTs allow manufacturers to provide fast-acting medication, add value to existing compounds and – imp…

Unique functional particles for excellent tabletting properties Parteck® SI, Merck’s outstanding, directly compressible sorbitol, is available in a variety of particle sizes and qualities for virtually any application you can imagine.The unique particle structure of Parteck® SI – loosely packed, needle-like crystals – gives it some quite distinctive physical properties making Parteck® SI the perfect excipient for combining ma…

The DRYPOUR™ packaging system for high-quality hygroscopic salts When it comes to products and workflow, you accept nothing but the highest quality in your production – so the same should apply to packaging. Our DRYPOUR™ packaging system is an outstanding new solution for our high-quality hygroscopic salts.This state-of-the-art design packaging system minimizes caking, thus significantly reducing the time needed for material…

Samplicity G2 Starter Bundle (Glossy Green) with 0.45 µm Millex-GP Filters

Immunohistochemistry Stains

Automated stainer for Hematology

HARLECO® Dyes & Stains

Detects apoptotic cells in situ by the indirect TUNEL method, utilizing an anti-digoxigenin antibody that's conjugated to a Fluorescein reporter molecule

Learn about our LentiBrite™ LC3 lentiviral particles and LC3-II Autophagy Enrichment Kits.  

Combining microscopy and flow cytometry, Amnis imaging flow cytometry systems provide bright-field, dark-field (SSC), and several fluorescent images of each cell in flow, at high speed. Paired with IDEAS® software for quantitative image analysis and population statistics, the technology gives you the ability to address complex biology that traditional flow cytometers can't resolve. Not only do the instruments reveal spatial lo…

Supel™ Genie HybridSPE® online cartridges have been developed as an alternative to traditional 96-well plate and individual cartridge formats for phospholipid removal and sample preparation. The HybridSPE online cartridges have been designed for online phospholipid removal allowing direct injection of protein precipitated samples for LC/MS analysis. When the samples flow through the HybridSPE online traps, the phospholipids ar…

Lyophilized powder, ≥96% (agarose gel electrophoresis)