SyncroPatch 384
The SyncroPatch 384 is a revolutionary automated patch clamp system combining high quality electrophysiological data acquisition and analysis with state-of-the-art liquid handling. With 384 amplifier channels and a 384-pipetting head, up to 384 cells can be recorded in parallel, resulting in a throughput of up to 20,000 high-quality data points per day.
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The SyncroPatch 384 is an automated patch clamp instrument with 384 recording channels incorporated into a state-of-art liquid handling robot. It can be used for screening large compound libraries but also for smaller screens and assay development using the 32-well mode of operation. This allows the instrument to be literally turned into a lower throughput instrument, using a fraction of the chip and pipetting head in multiples of 32 wells.
The SyncroPatch 384 can be used in all stages of drug discovery, from hit discovery through lead optimization to safety pharmacology, and can also be used for complex biophysical analysis of ion channels in academic research. Our dedicated team of electrophysiologists and engineers are committed to continuous in-house assay development, software, and hardware advancements, ensuring fast and custom-tailored solutions for your assay demands.
Benefits:
384 recording in parallel
32-well mode for smaller projects or assay development
Single- or multi-hole chips
Giga-seal recordings with up to 95% success rate.
Sample collection for concentration verification.
Up to 20,000 data points per day.
Advanced temperature control
Voltage and current clamp as standard
Unlimited compound application due to waste removal
On-deck compound preparation
Internal solution perfusion
Chips produced in-house; various resistances available.
Introducing SyncroPatch 384: Technical specifications brochure with interactive links
In this application note, Nanion Technologies presents the SyncroPatch 384, an advanced automated patch clamp system. It features a 32-well mode for flexible usage and cost-effective utilization of the NPC-384 chip. With advanced temperature control, current clamp capability, on-board cameras, and compliance with CiPA guidelines, it is suitable for various applications. The system offers a redesigned patch clamp module, HTS compatibility, and a user-friendly deck layout with integrated cameras. The RecoBox provides easy access to essential functions. The NPC-384 chip is available in different types and ensures accurate compound concentrations. The software package includes PatchControl 384 and DataControl 384 for data recording and analysis.
