Patchliner
The Patchliner is a fully automated patch clamp system which records from either 4 or 8 cells simultaneously. The HEKA EPC10 amplifiers, full control over the pipette speed, ability to change protocols on-the-fly and flexible add-ons for temperature control and dynamic clamp make this instrument the most versatile APC system on the market.
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The Patchliner is versatile yet robust, ideal for basic research of ion channel biophysics and mechanisms of action, sophisticated assays such as heat activation, right through to routine assays such as safety screening of hERG or other cardiac ion channels in accordance with the CiPA initiative.
The Patchliner is a medium throughput automated patch clamp system which comes as a 4 or 8 channel version. Experimental protocols are programmed using the PatchControlHT software which controls the Tecan robot for addition of solutions, cells and compounds, and controls the PatchMaster software for data acquisition. NPC-16 chips, the consumable for the Patchliner, can be loaded on the chip wagon and the instrument can run unattended for 48 recordings.
Features include:
- External & internal solution exchange
- Unlimited compound applications due to continuous waste removal
- Temperature Control
- Voltage & current clamp mode
- Dynamic clamp
- Single- and multihole chips
- Rseries compensation
- Minimized cell consumption option
Applications:
- Voltage and ligand-gated ion channel analysis
- Temperature-activated channel analysis
- Intracellular-activated ion channel analysis
- Whole-cell & perforated patch clamp mode
- Suitable for cell lines, primary cells and stem cells
