Amperia™ Protein Quantification System
The Amperia™ system combines compact hardware, assay-ready sensors, and integrated software to streamline protein quantification. Built to support scientists in discovery, development, and beyond, it delivers dependable data quickly and without unnecessary complexity — even from crude or complex samples.
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Amperia™ is a benchtop protein quantification system designed for speed, reliability, and accessibility. With rapid readouts and an intuitive workflow, it helps researchers generate high-quality results across a range of biomolecules, from antibodies to AAVs. The system avoids the complexity of optics or fluidics, instead using robust electrochemical sensing. Assay kits, pre-validated sensors, and integrated software provide a simple, reproducible workflow that fits directly into everyday lab practice.
Key Features:
- Fast: Designed for speed — from sample to result
- Reliable: Reproducible data across samples, users, and runs
- Accessible: Easy to set up and use — no specialist required
- Works directly with crude and complex samples
- Compact benchtop format, no optics or fluidics
- Seamless integration with assay kits and software
Applications:
- Antibody quantification
- AAV total capsid quantification
- His-tagged protein analysis
- Bioprocess development & optimization
Use case: His-tag protein expression screening from crude lysates
His-tagged proteins underpin work across structural biology, assay development, and drug discovery. When screening many constructs, teams need quick, quantitative readouts from crude lysates to decide what to scale and what to drop.
In this application note, Abselion demonstrates how by using a His-tag assay on the Amperia™ platform, teams can obtain reproducible concentration measurements directly from unpurified samples, informing expression and purification decisions earlier.
Supporting antibody quantification in biologic development
Monoclonal antibodies (mAbs) remain one of the most widely used therapeutic modalities across oncology, autoimmune diseases, and infectious diseases.
In this application note, Abselion demonstrates the Amperia™ platform, offering a streamlined alternative, enabling consistent, sensor-based mAb quantification directly from cell culture supernatants using an inverse occupancy assay format, with adaptable throughput and simplified setup.
Enabling His-tagged protein analysis in expression workflows
His-tagging is a widely used strategy for protein purification, screening, and assay development – offering simple affinity-based capture without altering protein function.
In this application note, Abselion demonstrates Amperia™, offering a practical alternative, enabling quantification of His-tagged proteins even from crude samples using a premix competition assay.
University of Manchester COEBP efficiently isolates 10x higher-producing CHO population using the Amperia RED system
In this application note, Abselion presents a study carried out by a team at the Centre of Excellence in Biopharmaceuticals (COEBP), University of Manchester, in which they sought to determine the effects of the addition of a chemical agent on cell productivity. The study found the Amperia RED system provides a robust alternative to ELISA for antibody titre analysis to quickly identify and rank high-producing clones in cell line development programs.
Empowering AAV quantification for gene therapy research
Adeno-associated virus (AAV) vectors have become a cornerstone of gene therapy, valued for their safety, broad targeting capabilities, and adaptability across therapeutic applications.
In this application note, Abselion demonstrates the Amperia™ platform, offering a streamlined alternative – using a sandwich-format assay with high-affinity antibodies from Thermo Fisher Scientific to quantify multiple AAV serotypes with robust performance across sample types.
Efficient and accurate quantification of human antibodies in Cell Line Development with the Amperia system
In this application note, Abselion presents a study conducted by Agenus UK, in which the accuracy of the Amperia™ (RED) system was shown to match BLI and SPR methods.
Amperia: Your companion for fast, reliable, accessible protein quantification
In this product brochure, Abselion demonstrates the Amperia™, an at-line compact benchtop instrument, designed to be a simple-to-use and cost-effective solution for rapid and accurate automated quantification of a range of biomolecules directly from unpurified samples in standard 96-well microplates.
TechTalk: Fast, accurate, accessible quantification across diverse biologics
Friday, January 23 at 16:00 GMT | 17:00 CET | 11:00 EST | 08:00 PST
Quantifying antibodies, AAV capsids, and tagged proteins directly from crude or partially clarified samples remains a common bottleneck in many biologics workflows.
In this 20-minute TechTalk, Dr. Paolo Romele, VP of Science, Abselion will introduce the electrochemical approach used in the Amperia™ benchtop platform, which combines affinity-based capture with Redox Electrochemical Detection (RED) to provide quantitative measurements without relying on optical readouts.
Join this educational and technology-focused session to learn practical examples illustrating how these assays operate across biologics applications.
Key learning objectives:
- Understand the principles behind affinity-based electrochemical assays using Redox Electrochemical Detection (RED) as implemented in the Amperia™ system.
- Learn how the three assay formats are applied to antibodies, AAV capsids, and tagged proteins.
- Review example data demonstrating assay behaviour with directly prepared samples.
- See how electrochemical detection can complement existing analytical approaches in biologics measurement.
Who should attend?
- Biotech and pharma scientists working with antibodies, AAV vectors, tagged proteins, protein expression, cell line development, or vector optimization.
- Research teams in early development focused on process design, screening, assay development, and exploring quantification methods beyond traditional optical assays.
Certificate of attendance
If you attend the live TechTalk, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
If you view the on-demand TechTalk, you can request a certificate of attendance by emailing editor@selectscience.net.
Abselion launches His-tagged Protein Quantification Kit and Sensors for Amperia
Ready-to-use solution, developed in collaboration with GenScript, offers rapid and reliable quantification of His-tagged proteins
