Agilent BioTek Synergy Neo2 Hybrid Multimode Reader
Agilent BioTek Synergy Neo2 multimode microplate reader features proprietary Hybrid Technology, with independent optical paths that ensure excellent performance in all detection modes. Variable bandwidth quad monochromators, sensitive high transmission filter-based optics, laser TRF, and up to 4 PMTs provide ultrafast measurements.
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Agilent BioTek Synergy Neo2 multimode microplate reader features proprietary Hybrid Technology, with independent optical paths that ensure excellent performance in all detection modes. Variable bandwidth quad monochromators, sensitive high transmission filter-based optics, laser TRF, and up to 4 PMTs provide ultrafast measurements.
Advanced environmental controls, including CO2/O2 control, incubation to 70°C, and variable shaking support live cell assays. BioStack Neo delivers walk-away automation, high throughput, barcode-labeled filter cubes to streamline workflows and limit errors. Powerful Agilent BioTekGen6 software provides complete reader control and powerful data analysis.
Kinetic degradation of IMiD molecular glues and their target families
In this application note, Agilent outlines the automation of parallel degradation and viability screening of several key immunomodulatory drug (IMiD) molecular glue targets, IKZF1 (Ikaros), GSPT1, and IKZF2 (Helios) with various IMiDs using the Promega Nano-Glo® HiBiT technology, in conjunction with the Agilent BioTek BioSpa 8 automated incubator and the Agilent BioTek Synergy Neo2 hybrid multimode reader. Targeted protein degradation of disease-causing proteins has proven to be a powerful therapeutic approach. The ability to monitor the specificity of degradation amongst related target classes at endogenous protein levels, continuously in live cells, is critical for understanding the efficacy and mechanism of these compounds.
Discover the Agilent BioTek Synergy Neo2 Hybrid multimode reader for screening laboratories
Discover the Agilent BioTek Synergy Neo2, a hybrid multimode reader specifically designed for screening laboratories, offering speed and ultra-high performance. It features variable bandwidth quad monochromators, high-transmission filter-based optics, laser time-resolved fluorescence (TRF), and up to four photomultiplier tubes (PMTs) for rapid measurements with outstanding results. Advanced environmental controls, such as CO2/O2 regulation and incubation up to 70°C, along with variable shaking, support live cell assays. Cell-based detection is enhanced by direct bottom illumination. The powerful Gen5 Software provides complete control of the reader, advanced data analysis, automation, and seamless Laboratory Information Management System (LIMS) integration.
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