Join Malvern For Expert Help on Protein Interaction Analysis with Microcal PEAQ-ITC at the 29th Annual Symposium of The Protein Society

Resolving challenges, finding solutions

8 Jul 2015
Lois Manton-O'Byrne, PhD
Executive Editor

Industry news

At the 29th Annual Symposium of The Protein Society (22-25th July, Barcelona, Spain) Natalia Markova, Principal Scientist- MicroCal, Malvern Instruments, will be presenting a workshop on how to enable high resolution protein interaction analysis using the latest MicroCal PEAQ-ITC system. Studies of biomolecular interactions are fundamentally important in all areas of the life sciences since such interactions drive and regulate all biological processes.

The workshop will address current challenges scientists face in interaction analysis through a Q&A panel session with calorimetry experts. A subsequent presentation will explain how the MicroCal PEAQ-ITC range of isothermal titration calorimeters, complete with new analysis software, deliver efficient analysis to relieve bottle necks and allow scientists to better understand biomolecular interactions. Data provided by the label-free interaction analysis that calorimetry delivers enable scientists in academia and industry to better understand binding events between almost any type of biologically relevant interactant. The new MicroCal PEAQ-ITC, the latest generation of the instrumentation, optimizes the study of protein interactions by improving signal stability, mixing and signal-to-noise characteristics.

Natalia Markova explains, “Among the most recognized challenges in interaction analyses are the needs to adequately address a broad range of binding affinities and to reliably interpret binding data complicated by the presence of inactive protein fractions or inherent uncertainty in the concentration of a ligand. The new MicroCal PEAQ-ITC, offers a whole range of solutions for addressing current pains associated with interaction analysis.”

The Annual Symposium of The Protein Society will focus on all aspects of protein science featuring prestigious speakers and numerous workshops for educators and students alike, providing networking opportunities for future collaborations. To discover more about the new MicroCal PEAQ-ITC and how to conduct high resolution protein interaction analysis, join Malvern Instruments for lunch on Wednesday 22nd July 12-1 pm.

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Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.CalorimetryCalorimetry is a technique used to determine the heat released or absorbed in a chemical reaction. Calorimeters can be categorized into bomb calorimeters, constant pressure calorimeters, differential scanning calorimeters, isothermal titration calorimeters, X-ray microcalorimeters, heat-loss calorimeters, and high-energy particle calorimeters. The choice of calorimeter depends on the application.Microflow CalorimeterProtein InteractionsProtein interactions are essential for understanding cellular processes, as proteins work together to carry out biological functions. Studying protein interactions can provide insights into disease mechanisms, drug development, and cell signaling pathways. Explore the best tools for protein interaction research in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Label-Free Analysis