MicroCal PEAQ-ITC Automated
High productivity measurement of multiple binding parameters.
MicroCal PEAQ-ITC Automated
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Great outcomes It is at the core of my study.
Analyze Binding interactions of lectin-glycopeptides
I am obtaining the thermodynamic parameters for my research utilizing Malvern's very sensitive ITC equipment. I was able to produce findings of a very high caliber, and Malvern's PEAQ ITC program is fantastic; I adore it. Although it is difficult to analyze the samples because many precautions must be taken, it is acceptable because we are only interested in binding affinities that are micromolar or lower because everything counts at that point. Additionally, customer support is excellent. Whenever I write about a problem, I always receive a response within 24 hours.
Review Date: 19 May 2023 | Malvern Panalytical
From less amount of sample can determine the interaction studies
Binding interaction studies
Malvern Microcal PEAQ-ITC Automated system is very easy to use. I love this instrument very much. Software for analysis is also very easy to determine the binding interaction studies.
Review Date: 10 Feb 2023 | Malvern Panalytical
Manufacturer's Response
Thank you so much for taking the time to send in the review. It was very kind of you. The development team put a lot of work into making the user experience and enjoyable one and will be so pleased to hear that you 'love it'.
The MicroCal PEAQ-ITC Automated is a configurable, low volume, highly sensitive isothermal titration calorimeter which offers the convenience of unattended operation. It delivers direct, label-free in solution measurement of all binding parameters in a single experiment. Applications include characterizing molecular interactions of small molecules, proteins, antibodies, nucleic acids, lipids and other biomolecules. It can also be used to measure enzyme kinetics.
The system directly measures heat released or absorbed during biochemical binding events, from which it calculates binding affinity (KD), stoichiometry (n), enthalpy (ΔH), and entropy (ΔS). Other than preparing samples and reagents to appropriate concentrations, there is minimal assay development and time to first result is fast. Easy-to use software includes optimized automation scripts for robust operation with a variety of sample types and conditions.
Features:
- User-friendly design tools assist in selecting experimental run parameters.
- All binding parameters (affinity, stoichiometry, enthalpy and entropy) in a single experiment.
- Quick to first result with minimal assay development, no labelling, no immobilization and no molecular weight limitations.
- High signal to noise gives more confidence in accessing data quality and relevance of generated affinity and thermodynamic parameters.
- Outstanding data quality for sub-millimolar to picomolar disassociation constants (10-2 to 10-12 M).
- Coin shaped cell optimizes sample mixing.
- Nonreactive Hastelloy for chemical resistance and compatibility with biological samples.
- Sensitivity to investigate any biomolecular interaction using as little as 10µg of protein.
- Samples presented in temperature controlled 96-well plate.
- Fully automated system with walk-away operation for enhanced productivity.
Interaction analysis masterclass with Malvern Panalytical
This Malvern Panalytical masterclass delves into the intricacies of interaction analysis and explores how ITC and GCI are complementary and orthogonal techniques for all early-stage drug discovery needs. Discover how ITC and GCI technologies can be applied to complex targets and interactions in a series of applications from hit identification to lead-optimization.
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