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Advances in drug discovery: supply chain trends, streamlined screening, improved off-target effect analysis, and more

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From tackling post-pandemic changes in the biopharmaceutical supply chain to addressing unmet therapeutic needs, simplified off-target effect analysis, and more, explore the latest advances in drug discovery with these free resources

20 Sept 2022
Blake Forman
Content Creator

Editorial article

Advances in Drug Discovery Special Feature

As part of our latest special feature, we’ve pulled together a selection of top new resources to support and advance drug discovery. Read on to explore post-pandemic changes to the biopharma supply chain, learn about a range of electronic pipettes which enable you to replicate all kinds of plates, gain insight into approaches to identify and reduce luminescence crosstalk, and much more.

bioCERTIFIED reagents from Spectrum Chemical

SUPPLY CHAIN: Streamlining biopharmaceutical practices

In this SelectScience® interview, Vivek Kumar, Spectrum Chemical, discusses post-pandemic changes in the biopharma supply chain and manufacturing timelines and how the bioCERTIFIED™ Quality Management System can save manufacturers time and resources.

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Scientist holding a multi-well plate

LIQUID HANDLING: How to transfer samples from plate to plate

Find out how the range of electronic pipettes from INTEGRA Biosciences enable you to replicate or reformat all kinds of plates – including 12, 24, 48, 96, 384, or 1536 well plates – quickly and easily.

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Preview of front page of app note on miniaturized luminescence-based assays

ASSAYS: Miniaturized luminescence-based assays to optimize results

Luminescence crosstalk negatively affects data quality increasing variability, background, and false positives. This application note from BMG LABTECH describes different approaches that enable you to identify and reduce crosstalk.

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Electronic pipette being used in a lab

PIPETTING: Streamline cell culture and reagent preparation

In this SelectScience article, discover an innovative new pipette controller, the BRAND® accu-jet® S, and top tips to help streamline cell culture work, reagent preparation, and general pipetting.

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Előd Körtvély, Roche Innovation Center, Basel

INTERVIEW: Complement in drug discovery: Addressing an unmet therapeutic need

In this SelectScience interview, Előd Körtvély, Roche Innovation Center, Basel, explains how the team in Ophthalmology strives to develop novel therapeutic approaches for major eye diseases.

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Scientist using the 2D-5D software platform from Thermo Fisher Scientific

SOFTWARE: Powerful imaging data toolbox can streamline drug discovery workflow

In this eBook, discover a multifaceted 2D-5D software platform from Thermo Fisher Scientific which offers a comprehensive toolbox of imaging processing methods that can be automated through custom detection workflows.

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Front page of app note on the characterization of drug off-target responses with MALDI MS

BIOMARKERS: Streamline characterization of drug off-target responses with MALDI MS

Discover a comprehensive workflow for interrogating lipid changes in microglia that combines MALDI MS whole-cell fingerprinting and high-throughput sample preparation using the Analytik Jena CyBio FeliX liquid handler.

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Video screenshot from 'flexible system for automated patch clamp experiments'

ION CHANNELS: Flexible system for automated patch clamp experiments

Discover how the versatile and flexible SyncroPatch 384, from Nanion Technologies GmbH, is equally well suited for large unattended high-throughput screening campaigns as well as for smaller projects.

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3D CELL MODELS: Automation compatible liver cell models streamline drug screens

Learn how you can improve your high-throughput screening results by creating more relevant and functional liver cell models with animal-free GrowDex® hydrogels from UPM Biomedicals.

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Additional drug discovery resources:

High-throughput cryo-EM epitope mapping of SARS-CoV-2 spike protein antibodies with Utrecht University and Takeda Pharmaceuticals: In this guest editorial article, learn how scientists are leveraging cutting-edge cryo-EM workflow advancements and their impact in drug discovery. Read article >>

A new frontier in medicine with robust cell & gene therapy delivery: In this interactive resource, we explore the different approaches available for safe and effective delivery of cell and gene therapies into target cells. Visit interactive hub>>

How to buy microplate readers: Microplate readers/detectors are the key workhorses in many laboratories and are used extensively for applications in drug discovery and assay development. In this free eBook download, we guide you through buying a new microplate reader by providing expert insight and the information you should consider when selecting the best technology for your lab. Download guide >>

The Swiss Army knife of ligand binding assays: While many biophysical analytical tools are suited for detecting structural changes, few can assess structure-dependent function in the same system. This interactive resource outlines the power of label-free protein-protein and protein-small molecule interaction characterization. Visit interactive hub >>

Managing the risk of nitrosamines in medicinal drugs: In this free eBook, discover a range of ultra-fast mass spectrometry technologies for the quantification of trace levels of nitrosamine impurities from various drug substances, drug products, and solvents.Download guide >>

Addressing the top 3 challenges in cell line development: Clonality assurance, regulatory-compliant data, and high product quality: In this article, we speak with a team of experts at Advanced Instruments to learn how labs can incorporate different instruments at specific points in the cell line development workflow to significantly improve timelines.Read article >>

Your recommendations:

Take a look at what researchers all over the world are saying about the latest equipment and technologies helping scientists. Here, Samuel Brown, New England BioLabs, shares his thoughts on the ASSIST PLUS by INTEGRA Biosciences.

Samuel Brown's Assist PLUS review

Find more news and resources in our Advances in Drug Discovery Special Feature>>

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Sample ManagementSample management systems include sample storage devices such as freezers and plate storers, sample environment enclosures and sample organization, retrieval and sorter systems. Useful system features include high-throughput, automation, robotic arms, automated liquid handling and associated database systems. Accessories in sample management include barcode scanners, heat sealers and tubes.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Automated Liquid HandlingAutomated liquid handling equipment is used to mix, dilute and dispense allotted volumes of liquid into microplates and other vessels automatically. The robotic, liquid handling arms can dispense from single channel to 3456 multichannel as well as operate nanoliter dispensing, enabling high throughput of samples. Find the best automated liquid handlers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.In Vivo Imaging Systems<i>In vivo</i> imaging systems, including pre-clinical imaging systems and medical imaging systems are used to non-invasively visualize and capture images of live animals and plants. Monitor the natural processes or diseases of your subjects using small-animal pre-clinical imaging systems, including single photon positron emission tomography (SPECT), positron emission tomography (PET), computed tomography (micro-CT), magnetic resonance imaging (MRI), X-ray radiography, ultrasound, fluorescence and bioluminescence imagers. Multimodal systems and software solutions are also available for correlative analysis of organ, tissue, cell, or molecular-level processes. Find the best in vivo imaging products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.Drug DiscoveryDrug discovery is the process of identifying potential new medications, involving stages such as target identification, compound screening, and preclinical development. It relies on cutting-edge technologies like high-throughput screening, artificial intelligence, and molecular modeling to accelerate the identification of drug candidates. Drug discovery plays a pivotal role in developing new therapies for diseases ranging from cancer to rare genetic disorders. Browse our peer-reviewed product directory to find the latest drug discovery technologies, compare options, check customer feedback, and get pricing directly from manufacturers.ScreeningUsing robotics, data processing and control software, liquid handling devices and sensitive detectors, screening allows a researcher to quickly conduct millions of chemical, genetic or pharmacological tests.Liquid HandlingLiquid handling involves the precise transfer, mixing, and dispensing of liquids in laboratory settings. It is essential for accurate and consistent results in biological, chemical, and pharmaceutical research. Automated liquid handling systems improve efficiency and reduce human error in sample preparation and analysis. Explore liquid handling tools in our peer-reviewed product directory; compare products, read customer reviews, and get pricing directly from manufacturers.Precision MedicinePrecision medicine refers to the idea of customized healthcare, where medical decisions and treatments are tailored to the individual patient. Molecular diagnostics, companion diagnostics and Next Generation Sequencing (NGS) play a pivotal role in this approach.

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