9 top new resources for your biopharmaceuticals research
Exclusive interviews, new methods, free downloads and much more to help advance your biopharmaceutical research
27 Jul 2020
Sophie Ball
Publishing / Media
Editorial article
As part of this month's special feature, we take a look at some of the latest technologies, resources, and techniques advancing biopharmaceuticals research and development. Discover methods for improved T cell expansion, learn how the latest mass detection technology can streamline routine biopharma analyses and find out more about antibody-dependent cell-mediated cytotoxicity.
Drug delivery: Understanding viral hijacking of extracellular vesicles
Virologist Dr. Ryan McNamara, UNC-Chapel Hill, discusses viral hijacking of extracellular vesicles, its potential for informing novel biotherapeutics, and how filtration technology from Thermo Fisher Scientific assists his research.
Cell culture: How to improve accuracy and consistency in cell culture research
Nate Starbard, Thermo Fisher Scientific, discusses how to overcome common filtration challenges in the lab.
Cell therapy: Optimized assay for improved T cell expansion protocols
Download this application note from Sartorius to discover how the need to monitor T cell phenotype and function for improved T cell expansion protocols was addressed with a T cell memory cell and cytokine profiling assay.
Mass detection: The key to faster biopharma analysis
Learn how Waters' mass detection technologies can streamline drug development, accelerate time-to-market, and enable greater productivity in routine biopharma analyses.
Immuno-oncology: Automated quantitative spatial analysis of tissue samples
Discover how using biomarkers on tissue samples not only provides new insights into the biology of cancer but ultimately enables a new level of patient stratification.
Viral titer: Measuring AAV concentration with multi-angle DLS
Find out how dynamic light scattering can be used in virus development to measure drug substance or for screening to separate good and stable samples from those with contaminants or aggregates.
Chromatography experts: Antibodies, Fc receptors and the immune system
Learn more about antibody-dependent cell-mediated cytotoxicity (ADCC), how antibodies fight cancers and infections and how Tosoh Bioscience can support you to better understand your antibodies.
Monoclonal antibodies: Analyzing bevacizumab, its aggregates and fragments
Learn how YMC-SEC MAB, the dedicated SEC column for antibodies by YMC Europe, can be used to separate antibody monomers from their aggregates as well as from degradation products in a single run.
PCR automation: Microplate sealing and peeling for high-throughput labs
Explore the key benefits of automating PCR, assay and compound storage plate sealing and peeling for medium to high-throughput laboratories.
More exclusive interviews:
- The new option for vacuum filtration in 50 ml cell cultures: faster multiparallel filtration using a multistation: We speak with Dr. Noushin Delmdahl, Head of Product Management Lab Consumables at Sartorius Lab Instruments, who introduces us to a newly available vacuum filtration system catering for 50 mL volumes and speeding up the filtration process, especially in high-density cell cultures. Read article>>
- Our mission to prevent Zika virus outbreaks: Learn about the development of a new Zika vaccine at the Instituto Butantan and key technology for maintaining consistency in immunobiological product production. Read article>>
- The transformative benefits of automation in high-throughput drug discovery workflows: Learn how unique automation of some of the most routine processes in a workflow can transform emerging biotechnology companies. Read article>>
Other resources in biopharmaceuticals:
- Flow imaging microscopy reveals particles missed by DLS and NTA: In this application note, Fluid Imaging Technologies shows how the FlowCam 8000 overcomes the challenges of traditional particle analysis methods, such as dynamic light scattering (DLS) and nano-particle tracking (NTA). Download Guide>>
- How to Buy Microplate Readers: In this free eBook download, we guide you through buying a new microplate reader by providing expert insight and all the information you should consider to select the best technology for your lab. Download Guide>>
- How to Buy DNA/RNA and Purification and Quantification Technology: This eBook provides useful resources, expert insight, and application-based case studies to help simplify your choice when it comes to choosing the best DNA/RNA and purification and quantification technology for your applications. Download eBook>>
- How to Buy Liquid Handling Technology: In this free eBook download, we guide you through buying new liquid handling equipment by providing expert insight and the information you should consider to select the best pipettes or automated liquid handling systems. Download eBook>>
Your recommendations:
Take a look at what other researchers and scientists all over the world are saying about the latest equipment and technologies in biopharmaceutical research. Bailin Liang, from Johnson and Johnson Vision Care Inc, shared his opinion on the Nalgene™ Rapid-Flow™ sterile disposable filter units with PES membrane by Thermo Fisher Scientific:
Find more news and resources in the Biopharmaceuticals Special Feature>>
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Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.Lab-on-a-ChipLab-on-a-chip (LOC) technology uses microfluidic chips, such as microarrays, to perform biochemical assays on a small scale. Benefits of lab-on-a-chip include the small volume of sample required as well as the speed of analysis. In selecting lab-on-a-chip devices consider the assay, cost, reliability, sensitivity and signal to noise ratio.Compound LibrariesCompound libraries, or chemical libraries, are used in drug discovery for the identification of potential therapeutics compounds. Used in conjunction with high-throughput screening, the libraries of stored compounds are often generated for specific purposes as a drug target or disease model. Cheminformatics are commonly used when designing a compound library and software can be used to analyze the screening process. Process ChemistryProcess chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Plate ProcessingAutomated plate processing is used in microplate technologies for high-throughput, speed and efficiency. Plate processing systems include microplate handlers for moving plates, heat sealers, stackers and carousels for storage, retrieval and delivery, microplate washers and piercers. Useful features of plate processors include walk-away automation, compatibility and easy integration with microplate systems.GC-MS GC-MS (gas chromatography-mass spectrometry) instruments and equipment are used to separate, quantify and identify mixtures of small and volatile compounds, such as polycyclic aromatics, fatty acids and alcohols. Often used in drug detection, forensic investigation and environmental analysis for pesticides and contaminants, GC-MS is a powerful addition to your lab’s analytical capabilities. GC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzers can give greater sensitivity and resolution to your analysis. Find the best GC-MS instruments and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.PCR and Thermal CyclingPolymerase chain reaction (PCR) kits and thermal cyclers are used for the in vitro amplification of DNA permitting subsequent analysis and experimental procedures. Explore a range of high-quality polymerase, primers and nucleotides or simplify your workflow with a PCR mastermix. Find reverse transcription PCR (RT-PCR) and cDNA synthesis kits for RNA products and libraries. Quantitatively measure the amplification of DNA with real-time PCR (qPCR) and droplet digital PCR (ddPCR) kits and systems, and discover automated PCR setup solutions to increase throughput. Alternative DNA amplification methods also include recombinase polymerase amplification (RPA) kits. Find the best PCR kits and thermal cyclers and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Monoclonal AntibodiesMonoclonal antibodies (mAbs) are lab-made molecules that can bind to specific antigens on cells, making them highly effective in treating cancers, autoimmune diseases, and infections. These targeted therapies are transforming the treatment landscape for many conditions. Browse our peer-reviewed product directory to find monoclonal antibodies for research and clinical applications; compare products, check reviews, and get pricing directly from manufacturers.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.Cell TherapyCell therapy involves using living cells to treat diseases, often by replacing damaged cells or stimulating regeneration. Stem cell therapy and CAR-T cell therapy are examples of cutting-edge treatments in regenerative medicine and cancer immunotherapy. Browse our peer-reviewed product directory to find the best cell therapy tools, compare products, check reviews, and get pricing directly from manufacturers.ChromatographyChromatography is a powerful technique used to separate and analyze components of mixtures based on their chemical properties. It is widely used in fields like biochemistry, pharmaceuticals, and environmental analysis. By exploiting differences in the interaction of substances with a stationary phase and a mobile phase, chromatography enables precise purification and quantification of compounds. Whether you're working with complex biological samples or industrial chemicals, chromatography is essential for obtaining high-quality results. Browse our peer-reviewed product directory to find the best chromatography systems, compare products, read customer reviews, and get pricing directly from manufacturers.Drug DiscoveryDrug discovery is the process of identifying potential new medications, involving stages such as target identification, compound screening, and preclinical development. It relies on cutting-edge technologies like high-throughput screening, artificial intelligence, and molecular modeling to accelerate the identification of drug candidates. Drug discovery plays a pivotal role in developing new therapies for diseases ranging from cancer to rare genetic disorders. Browse our peer-reviewed product directory to find the latest drug discovery technologies, compare options, check customer feedback, and get pricing directly from manufacturers.VirusesViruses are microscopic pathogens that require a host cell to replicate. Understanding their structure, replication cycle, and impact on the immune system is crucial in developing effective treatments, vaccines, and diagnostic methods. Research continues to focus on emerging viral diseases and antiviral drug discovery. Explore solutions for virus research, detection, and treatment in our peer-reviewed product directory; compare products, check customer reviews, and get pricing directly from manufacturers.Cell Based AssaysCell-based assays use living cells to measure biological responses to various treatments or stimuli. They are essential for drug discovery, toxicology testing, and understanding cellular mechanisms. These assays are used to assess cell viability, proliferation, gene expression, and other cellular activities. Browse our peer-reviewed product directory to find the best cell-based assay tools and reagents, compare products, read customer reviews, and get pricing directly from manufacturers.
