Tips and tricks for developing orally bioavailable PROTACs

Prof. Zoran Rankovic explores the role of target protein degradation in drug discovery, with a focus on fusion oncoproteins. He introduces molecular glues, explaining their advantages and the design challenges involved. Prof. Rankovic also discusses the creation and screening of compound libraries, emphasizing their potency against cancer cell lines. The mechanism of action is examined through proteomics, and he addresses key challenges, including the Rule of Five and chemical stability, which are critical for developing orally bioavailable PROTACs.

This presentation was filmed at ELRIG Drug Discovery 2024.