SPEAR Technology: An immunoassay workflow with the sophistication of nucleic acid testing paradigms
25 Mar 2025
Successive Proximity Extension Amplification Reaction (SPEAR) technology offers unprecedented sensitivity for protein biomarker measurement while maintaining a simple, wash-free workflow. These unique features position SPEAR as a game-changing tool for developing blood-based biomarker assays, addressing long-standing challenges in neurology.
In this session, Dr. Feng Xuan explains the development of SPEAR and how it fundamentally differs from conventional ultra-sensitive immunoassay technologies. Key performance data using SPEAR to quantify and differentiate several low-abundant neuro biomarkers, as well as current applications and future possibilities for SPEAR are also discussed.
About the company
Spear Bio
Spear Bio – founded in 2021 and headquartered in Woburn, Massachusetts – is an innovative leader in providing scalable solutions for ultra-sensitive protein biomarker measurements. Spear Bio’s proprietary technology, Successive Proximity Extension Amplification Reaction (SPEAR), employs a unique 2-factor authentication mechanism to precisely measure protein biomarkers at attomolar level from sub-microliter sample volume. Spear Bio is focused on leveraging its technology’s unprecedented sensitivity to transform protein research and early disease diagnosis.