Protein Analysis Platform Poster
22 Feb 2012
This poster presentation describes the automated vibe platform, used to identify the optimum yield for protein purification of expressed proteins. Adam Hill, Novartis presents to SelectScience, a summary of the research carried out by Novartis and Bioscale.
About the company
BioScale, Inc.
At BioScale, we develop, manufacture and promote a sophisticated protein measurement technology to accelerate drug discovery, development and production of biological and pharmaceutical products. The simplicity, power and speed of our innovative technology enables our customers to achieve major advancements in protein research that were not previously attainable by allowing the ultra-sensitive detection of proteins in multiple types of complex biological samples. Key applications are available for bioprocess and biologics-oriented scientists that uniquely addresses impurity testing and product titer needs with highly reproducible detection and quantitation in complex biological mixtures. Used across the drug development spectrum including early discovery and development, preclinical development and clinical trials, typical applications include biomarker discovery, biomarker monitoring, pharmacokinetics, pharmacodynamics, toxicokinetics and protein expression.
BioScale was founded in 2002 by CEO Mark Lundstrom and three interdisciplinary MIT professors. Since then the Company has assembled development, engineering, manufacturing and an industry-seasoned commercial team to globally launch our AMMP assay technology and ViBE platform into the pharmaceutical, biotech, life science, and bioprocess markets. We are also pursuing partnering for diagnostic and specialty applications. The Company's 30,000 sq. ft. global headquarters and manufacturing site are located in Lexington, Massachusetts.
Related products
Request Quote for All Products
ViBE BioAnalyzer
BioScale, Inc.The compact, benchtop ViBE BioAnalyzer is the ideal research tool for assay development or small to medium size studies which require highly-sensitive detection and quantitation of proteins in complex biological mixtures with real-time results. The small foot-print BioAnalyzer can be easily scaled-up to a ViBE Workstation for higher throughput and walk-away operation. The ViBE BioAnalyzer • Ideal for research applications and assay development • Simple manual operation • Simultaneously process eight samples • Upgrades to a ViBE Workstation for walk-away operation as sample load increases • Detects and quantitates proteins in complex biological mixtures
ViBE Protein Analysis Workstation
BioScale, Inc.ViBE Protein Analysis PlatformPowered by AMMP Technology, the ViBE platform allows rapid design and configuration of protein assays to achieve highly-sensitive detection and quantitation of proteins in complex biological samples with real-time results. The ViBE platform … • Open assay design allows use of your own antibodies and the ability to define sensitivity, dynamic range, and speed requirements for efficient process workflow. • Simple yet sophisticated AMMP assay format is able to selectively separate your analyte from the “noise”. • Rapid design, configuration and ease of methods transfer reduce the time for assay validation. • In a hurry? The ViBE platform can provide ELISA-like results in 20 minutes for a quick screening assay. • Unlike automated ELISAs, ViBE products provide “real time” results. • Data output from the ViBE Software are easy to interpret. AMMP Assays—Simple. Sensitive. Sophisticated AMMP assays use a traditional homogeneous assay format with a proprietary detection technology providing confident results, fewer sample limitations, simple operation and fast assay development. AMMP is the unique integration of magnetic microparticles, a universal sensor and acoustic detection, creating a protein detection technique that is highly robust and versatile. Non-optical detection AMMP non-optical protein detection technology has proven correlation with optical measurements but with broader detection limits and less sample prep. Non-optical detection and mechanically amplified signal allows measurement of low expressing proteins otherwise lost in baseline noise and less baseline interference reduces the need for multistep dilutions especially in complex samples. Complex matrices without the complexity Non-optical AMMP detection, assay flexibility and enhanced sensitivity enable the ViBE platform to analyze proteins from a variety of complex matrices. The ViBE platform has shown superior results in tissue, tumor, plasma, serum, urine, stool and bioreactor samples at concentrations as low as pg/mL ViBE Technical Performance • Enhanced Sensitivity – down to the sub-picogram level • Exceptional Reproducibility-- 5-10% CVs plus outstanding instrument to instrument repeatability • 3-log dynamic range