Fighting Antibiotic Resistance at the Point of Care

5 Jul 2017
Fighting Antibiotic Resistance at the Point of Care

Antibiotic resistance is a major, growing threat to human health worldwide. There is an urgent need to develop easy-to-use, sensitive tests that can detect drug resistance at the bedside, so that appropriate, potentially life-saving antibiotics can be prescribed without delay.

This video presents a team at the University of Southampton led by professor Hywel Morgan, who have developed a cost-effective, highly-sensitive and portable digital microfluidic device to quantitatively detect antimicrobial resistance genes in DNA extracted from patient samples, with the aim of incorporating it into a point-of-care system

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TwistDx

TwistDx designs and manufactures Recombinase Polymerase Amplification or RPA, a multiplexable, isothermal DNA/RNA amplification and detection technology that works amazingly fast without the need of a thermocycler. RPA is a portable alternative to PCR and is ideally suited to point-of-use molecular assays for digital, microfluidics, agriculture, veterinary and biodefense applications.

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