SelectScience InterviewsLife Sciences
Biomarkers in prostate cancer: Insights from discovery to clinical application
1 May 2025
Dr. Nallasivam Palanisamy (Associate Scientist, Department of Urology, Henry Ford Health and Associate Professor of Research, Michigan State University) explores how next-generation sequencing (NGS) is transforming prostate cancer care. He highlights the discovery of RAF kinase and pseudogene-related gene fusions, and explains how NGS enables precise detection of complex genetic changes. These insights are helping guide clinical decisions, from risk assessment to personalized treatment, by accounting for tumor heterogeneity and the interplay of genetic, epigenetic, and environmental factors.
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BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Next Generation SequencingNext-generation sequencing (NGS), also known as whole-genome sequencing, high-throughput sequencing and massive parallel sequencing, produces and analyses thousands to millions of nucleotide sequences at once. Sequencing systems operate via varying technologies depending on the manufacturer, including sequencing by synthesis, ligation, pyrosequencing, ion semiconductor and single-molecule real-time sequencing. For NGS, library preparation is paramount to successful sequencing. In this section, explore a range of library preparation kits, from targeted, amplicon-based or hybridization-based kits including epigenomic, transcriptomic and genomic workflows to fragmentation kits. Find the best next-generation sequencing products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Prostate CancerCancer ResearchCancer research aims to understand the mechanisms of cancer development and progression to improve prevention, diagnosis, and treatment. From molecular biology to clinical trials, research spans a wide range of disciplines, including immunotherapy, targeted therapies, and drug discovery. Explore the best cancer research products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.