ResourceDrug Discovery & Development
Vanoxerine, a New Drug for Terminating Atrial Fibrillation
17 Oct 2010Vanoxerine is a dopamine transporter antagonist that was developed for treatment of Parkinson’s disease and depression, but had no effect on these diseases. This application note demonstrates that vanoxerine is highly effective in terminating atrial fibrillation (AF) or atrial flutter (AFL) in dogs with sterile pericarditis (SP) and has the potential to become a valuable antiarrhythmic agent.
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Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.Process ChemistryProcess chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.