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Using spatial phenotypic signatures to predict immunotherapy response

Akoya Biosciences
21 Apr 2021

In this infographic, discover how spatial phenotypic signatures can act as invaluable whole slide image-based quantitative biomarkers to predict immunotherapy response, and learn more about Akoya Biosciences’ comprehensive multiplex immunofluorescence solutions for spatial phenotyping.

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PhenoImager® HT

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PhenoImager ® HT (formerly Vectra ® Polaris™) is the fastest and most highly cited whole-slide, single-cell resolution imaging platform for spatial phenotyping and the development of spatial signatures. Featuring Akoya’s patented Multispectral Imaging (MSI) and spectral unmixing technologies, this platform can be easily integrated into high-throughput workflows to accommodate projects regardless of your scale. 

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PhenoCycler®

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The PhenoCycler ® is a cutting-edge fluidics control unit that integrates with the PhenoImager Fusion imaging platform creating the fastest spatial biology solution with unparalleled throughput. 

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BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Cancer DiagnosticsThere are a wide variety of diagnostic tests for cancer available, and this range continues to expand as our knowledge of cancer improves. Current diagnostic methods include biopsy, imaging and blood tests for known biomarkers. New methods in research development include liquid biopsies and cancer breathalyzers.Cancer ResearchCancer research aims to understand the mechanisms of cancer development and progression to improve prevention, diagnosis, and treatment. From molecular biology to clinical trials, research spans a wide range of disciplines, including immunotherapy, targeted therapies, and drug discovery. Explore the best cancer research products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.ImmunophenotypingPhenotypic ScreeningPhenotypic screening assesses cellular responses to compounds, enabling drug discovery and target identification. This technique is pivotal in finding effective treatments for complex diseases. Discover phenotypic screening platforms and tools with peer-reviewed comparisons and pricing in our directory.Biomarker DiscoveryClinical biomarkers refer to substances related to known medical conditions that can be accurately measured <i>in vitro</i>. Biomarkers can be used to diagnose presence of a disease and indicate disease severity. The discovery of new biomarkers is incredibly valuable in the field of diagnostics.

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