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Using a process Raman analyzer as an in-line tool for accurate protein quantification in downstream processes

Thermo Fisher Scientific
9 Dec 2025

Therapeutic proteins are used to treat a variety of conditions and diseases such as cancer, immunologic diseases, communicable diseases like COVID-19, and many others. Thus, ensuring the quantity and quality of therapeutic proteins throughout the manufacturing is of paramount importance.

Explore a study that was carried out that measured mAb concentration using the Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer. Discover how this in-line process analytical technology (PAT) solution enables real-time monitoring that reduces batch-to-batch variability to support product uniformity.

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Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer

Thermo Fisher Scientific

The Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer enables real-time, accurate spectral results for process monitoring. MarqMetrix All-In-One Process Raman Analyzer redesigns how Raman spectroscopy brings value to the Process Analytical Technology workflow by focusing on a user-centric experience through its rapid setup, portability, and ease of use for upstream and downstream R&D applications.

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Protein QuantificationThe detection and quantification of proteins in a sample is vital across life sciences, pharmaceutical research and clinical diagnostics, and a variety of equipment is available to scientists to simplify the workflow. Proteins of interest can be easily labeled and detected on light-based detection instruments. Immunoassay kits allow you to identify a specific protein of interest and protein detection beads or antibody microarrays allow you to identify multiple specific proteins at once. Protein interactions and enzyme activity can also be monitored with protein-protein interaction assays. Additionally, the biophysical characterization of proteins is made easy with biokinetic analyzers. Find the best protein detection and quantification products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.

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Using a process Raman analyzer as an in-line tool for accurate protein quantification in downstream processes