ResourceDrug Discovery & Development
The critical role of evidence-based databases in pharmacogenomics
9 May 2025In the high-stakes field of pharmacogenomics (PGx), precision and accuracy are non-negotiable. Evidence-based databases in PGx are indispensable tools that enable labs to interpret genetic variants confidently and accurately.
Trusted databases, such as PharmVar, CPIC, and PubMed, serve as vital resources for interpreting the impact of genetic variations on drug response. However, leveraging these databases effectively — and avoiding outdated or low-quality sources – is essential to ensuring the most accurate, relevant, and timely care.
Explore Pharmacogenomic Insights (PGXI) – a streamlined knowledgebase from QIAGEN® that can efficiently submit test results to identify relevant gene-drug associations, conditions, and literature evidence.
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ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :