Targeting natural killer cell activity with humanized NSG-IL15 mouse model
15 Mar 2021In this application note, The Jackson Laboratory demonstrate how the cord blood CD34+ hematopoietic stem cell (HSC) humanized NSG™-IL15 mouse enables in vivo efficacy research for compounds targeting human natural killer (NK) cell activity including antibody-dependent cellular cytotoxicity (ADCC).
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Animal ModelsThe use of non-human animals in experiments or behavorial observations. The research is conducted inside universities, medical schools, pharmaceutical companies, farms, defence establishments, and commercial facilities that provide animal-testing services to industry. It includes pure research such as genetics, developmental biology, behavioral studies, as well as applied research such as pharmaceutical testing in pre-clinical, before human, studies. Stem Cell ResearchStem cells have the ability to produce identical daughter cells as well as progeny, which commit and differentiate. Stem cell research has exciting prospects of biomedical applications in cellular disease modeling, pharmaceutical screening, and regenerative medicine.