Characterization of the Brain-Chip R1 as a first-in-class isogenic model of the human neurovascular unit

8 Dec 2025

This application note details the development and characterization of Emulate’s Brain-Chip R1, a first-in-class isogenic Organ-Chip model of the human neurovascular unit. Integrating five iPSC-derived cell types within a perfused microenvironment, the model forms a tight, stable BBB-like barrier and supports physiologically relevant studies of transport, neuroinflammation, and NVU function.

Brain-Chip R1

Emulate

Brain-Chip R1 A first-in-class, isogenic model of the human neurovascular unit

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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.organ-on-a-chipNeuroscienceNeuroscience research investigates the neurological mechanisms underlying behavior, neurodegenerative diseases, and other brain conditions. Learn about the innovative technologies for bioimaging, electrophysiology, cell culture, chromatography and other techniques used in this field.
Characterization of the Brain-Chip R1: A first-in-class isogenic model of the human neurovascular unit