ResourceDrug discovery > Basic Research
Solid-phase extraction solution for bioanalysis of therapeutic oligonucleotides
29 Jul 2025Explore the Biotage® Oligo SPE, a solid-phase extraction (SPE) solution specifically developed for efficient extraction of oligonucleotide-based therapeutics from biological samples, including plasma, serum, urine and tissue homogenates. Discover how by using mixed-mode weak anion exchange (WAX) chemistry, Biotage® Oligo SPE effectively removes interfering proteins, salts, sugars, lipids and DNA fragments. Its tailored sorbent design delivers clean extracts and consistently high recoveries across a variety of oligonucleotide structures and chemistries.
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Biotage® Oligo SPE
BiotageSolid-phase extraction solution for bioanalysis of therapeutic oligonucleotides
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OligonucleotidesOligonucleotides are small nucleic acid polymers, usually less than 20 bases in length. Oligonucleotides can be made via enzymatic cleavage or more commonly by chemical synthesis with polymerases. Their use includes FISH, southern blots, microarrays and as primers in PCR. High fidelity synthesis kits and detection systems are available for easy production and detection, respectively.Solid-Phase ExtractionSolid-phase extraction (SPE) is used for clean-up, extraction and concentration of semi-volatile or non-volatile analytes from complex mixtures including blood, urine and food samples. Multiple formats are available for conducting SPE, including prepacked SPE cartridges, disks and microplates, as well as SPE sorbent powders for manual packing. SPE systems can be used to automate the process and extract multiple samples at once. Solid-phase microextraction (SPME) and supported liquid extraction (SLE) products are also available in the same formats. Find the best SPE, SLE and SPME equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BioprocessingBioprocessing is the use of biological systems for the conversion of raw materials to desired products. This includes the research, development and manufacturing stages of production and can refer to food processing, small-molecule pharmaceutical manufacture, production of recombinant protein therapeutics, or the generation of renewable energy.PurificationPurification techniques are essential for isolating compounds of interest from complex mixtures, such as proteins, nucleic acids, and chemicals. These techniques are critical in biochemistry, drug development, and environmental studies. Explore purification systems in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.