Reproducible Burst Release from Time-Delayed Tablets Independent of pH and Hydrodynamic Agitation
12 May 2014It has long been recognized that agitation rate has a profound effect on tablet disintegration and drug dissolution, and the changing hydrodynamic environment of the gastrointestinal tract (GIT) is thought to contribute to the variability of solid oral dosage form performance in vivo. The experiment described in this poster determines robustness of the lag time before drug release in vitro for a press coated time-delayed tablet formulation, designed to perform independently of the variable local hydrodynamic environment of the GIT.
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Drug DeliveryDrug Delivery refers to dosage form, route of administration, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. Drug delivery is often approached via the biopharmaceutical or small molecule drug's formulation, but it may also involve medical devices or drug-device combination products. Considerations include instrumentation, software and services. Drug DosageDosage is the size or frequency of the administration of a drug. Determination of the dosage of a drug is critical in pharmaceutical development to ensure the optimum balance between efficacy and toxicity.