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Rapid thermal stability screening and selection of monoclonal antibody drug products

TA Instruments - Waters LLC
23 Jan 2026

Short-term thermal stability testing is crucial to ensure product quality and support regulatory approval of antibody drug products. Explore data illustrating how the TA Instruments™ RS-DSC (Rapid Screening-Differential Scanning Calorimeter) provides a new platform for characterizing antibody drug product stability, and how it enables high-throughput screening for thermal stability through simultaneous testing of up to 24 samples, significantly improving time to decision.

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Rapid Screening-Differential Scanning Calorimeter

TA Instruments - Waters LLC

The Next Generation of Thermal Stability Testing for Biologic Drugs The TA Instruments RS-DSC (Rapid Screening-Differential Scanning Calorimeter) is a powerful and versatile instrument that revolutionizes the thermal stability testing of biologic drugs with its high efficiency and streamlined analysis.

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CalorimetryCalorimetry is a technique used to determine the heat released or absorbed in a chemical reaction. Calorimeters can be categorized into bomb calorimeters, constant pressure calorimeters, differential scanning calorimeters, isothermal titration calorimeters, X-ray microcalorimeters, heat-loss calorimeters, and high-energy particle calorimeters. The choice of calorimeter depends on the application.AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Monoclonal AntibodiesMonoclonal antibodies (mAbs) are lab-made molecules that can bind to specific antigens on cells, making them highly effective in treating cancers, autoimmune diseases, and infections. These targeted therapies are transforming the treatment landscape for many conditions. Browse our peer-reviewed product directory to find monoclonal antibodies for research and clinical applications; compare products, check reviews, and get pricing directly from manufacturers.Thermal Stability

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Rapid thermal stability screening and selection of monoclonal antibody drug products