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Rapid peptide mapping and monitoring of post translational modifications using high resolution ion mobility mass spectrometry

MOBILion Systems
17 Jun 2021

In this application note, explore how MOBILion’s HRIM-MS platform can be used as a high throughput alternative to long LC-MS gradients by providing a rapid peptide mapping protocol.

Incorporating HRIM into an LC-MS workflow provided >96.5% sequence coverage in just 20 minutes total analysis time and included critical structural information that would have been missed using conventional LC-MS techniques alone.

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MOBILion Systems

MOBILion Systems is disrupting the separations game, enhancing the way we characterize biotherapeutics and identify biomarkers. Leveraging a 13-meter ion mobility path length to provide deeper level characterization without compromising time, our best-in-class SLIM-based High-Resolution Ion Mobility Mass Spectrometry (HRIM-MS) platforms separate and identify molecules that current platforms fail to detect with faster analysis and simpler workflows.

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Peptide MappingIon Mobility Spectrometry

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Rapid peptide mapping and monitoring of post translational modifications using high resolution ion mobility mass spectrometry