MOBIE
MOBILion Systems is disrupting the separations game, enhancing the way we characterize biotherapeutics and identify biomarkers. Leveraging a 13-meter ion mobility path length to provide deeper level characterization without compromising time, our best-in-class SLIM-based High-Resolution Ion Mobility Mass Spectrometry (HRIM-MS) platforms separate and identify molecules that current platforms fail to detect with faster analysis…
The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.
MOBILion Systems is disrupting the separations game, enhancing the way we characterize biotherapeutics and identify biomarkers. Leveraging a 13-meter ion mobility path length to provide deeper level characterization without compromising time, our best-in-class SLIM-based High-Resolution Ion Mobility Mass Spectrometry (HRIM-MS) platforms separate and identify molecules that current platforms fail to detect with faster analysis and simpler workflows.
Enhanced Resolution:
MOBIE separates and identifies molecules other instruments fail to detect with unprecedented resolution.
Increased Throughput:
Sample analysis takes place in minutes not hours. Run 1,000 samples/week vs. 1,000 samples/year. Get information sooner to make decisions faster.
Simplified Workflows:
Reduce reliance on liquid chromatography with digitized separations and easily transferrable methods. Reduce human errors and costs while increasing instrument uptime.
Run routine characterization assays for biologics in minutes on a single instrument:
- Two-minute, high-resolution released glycan analysis
- Peptide Mapping with PTM monitoring in 20 minutes or less
- Identify PTMs missed by LC/MS alone
- End-to-end workflow solutions from data acquisition through data processing with proprietary Protein Metrics BYOS® Software Modules
Unravel the subtleties of targeted glycomics and lipidomics with unparalleled resolution :
- Reduce reliance on Liquid Chromatography.
- Separate previously indistinguishable molecules in just two-minutes
- Realtime method development and simple method transfer
Revealing novel compounds in the biochemical hemp haystack using high-resolution ion mobility
In this application note, MOBILion Systems, Inc. delves into the challenges of developing therapeutic agents from natural extracts. The complexity of these extracts, with their diverse chemical compositions, poses significant hurdles in identifying bioactive compounds. The presence of isomers, molecules with identical formulas but differing spatial arrangements, adds further complexity. The note showcases the utility of high-resolution ion mobility (HRIM) by analyzing 28 cannabinoids from cannabis sativa. The application of HRIM provides advantages like separating isobaric and isomeric compounds, potentially increasing sensitivity by reducing background noise, and adding collision cross section as a complementary identifier to mass spectra. The study employed a simple and rapid liquid chromatography method utilizing Agilent 1290 LC, an integrated MOBILion Systems MOBIE® instrument, and an Agilent 6546 Q-TOF for the analysis of 28 cannabinoids, including 15 isomers.
Shining a high-resolution ion mobility light on PFAS dark matter for forensic fingerprinting
In this application note, MOBILion Systems, Inc. explores the challenges posed by per- and polyfluoroalkyl substances (PFAS), known as 'forever chemicals,' due to their elusive nature and limited detection methods. The concept of PFAS 'dark matter' refers to compounds undetectable by conventional techniques, leading to gaps in our understanding. The note introduces forensic fingerprint analysis as a promising tool, utilizing high-resolution ion mobility (HRIM) coupled with high-resolution mass spectrometry (HRMS) to shed light on PFAS distribution, impact, and mitigation. By integrating HRIM with existing liquid chromatography methods, this approach can identify branched isomers and provide a more comprehensive understanding of these persistent compounds. The study successfully resolved 11 isomers, including previously unresolvable compounds, highlighting the potential of HRIM in enhancing PFAS analysis.
A single flexible platform for high-resolution lipid analysis
In lipidomics, the challenge is accurately identifying isobaric and isomeric species in lipidomes. This shift from untargeted to targeted lipid analysis demands advanced solutions due to complex structures. Current methods struggle to resolve these issues. This application note shows how the MOBIE® platform provides a uniquely flexible platform that can be tailored to suit different lipid workflow solutions.
High-throughput monitoring of biotherapeutic critical quality attributes with high-resolution ion mobility-mass spectrometry
In this application note, MOBILion Systems demonstrates the benefit of incorporating high-resolution ion mobility (HRIM) into traditional LC-MS workflows for reproducible high-throughput targeted post-translational modifications (PTM) analysis for biopharmaceutical characterization.
Use of high-resolution ion mobility for PFAS isomer separation
Due to growing concern over their toxicological significance, analytical methods for PFAS (Per- and Polyfluoroalkyl Substance) are continuing to evolve. Targeted methods have historically been utilized with liquid chromatography and tandem mass spectrometry (MS/MS) the predominate combination used. In this application note, MOBILion Systems demonstrates the combination of liquid chromatography (LC), high-resolution ion mobility (HRIM), and high-resolution mass spectrometry (HRMS) for PFAS analysis.
