Rapid Evaluation of Compound Allergenicity by Measuring Histamine Release on Stimulated Whole Blood
5 Dec 2018This study demonstrates the capability of the HTRF Histamine-Dynamic kit to measure histamine release in whole blood samples treated with different allergen mixes. Investigating histamine release in fresh blood enables a rapid assessment of immunogenicity reactions and thus aids in efficiently predicting the safety of drug candidates.
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Histamine assay kit
Cisbio BioassaysA homogeneous single plate assay for the sensitive quantification of histamine.Histamine is a small biogenic amine that plays an important role in several physiological and pathophysiological processes. The histamine HTRF® assay is based on the competition between sample histamine and XL665-labeled histamine for binding to a Cryptate-labeled antibody. The amount of histamine detected is inversely proportional to the specific fluorescence emitted. The assay covers a measurement range of 10 to 400 nM with a detection limit of 1.5 nM.